Anti-Bacterial Drug Discovery Using Systems Biology

Author(s): K. D. Kumble.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 6 , Issue 11 , 2006

Abstract:

The pipeline for new antibacterials is bleak despite the fact that infectious diseases account for a quarter of all worldwide deaths due to disease. Bacteria are ideal organisms for a systems biology approach to understanding pathogenesis by combined use of genomic technologies and computer algorithms. This approach can be applied to identify control points in molecular networks, which could be targets for novel drugs.

Keywords: Genomics, systems biology, molecular networks, antibacterials, pathogens

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Article Details

VOLUME: 6
ISSUE: 11
Year: 2006
Page: [1275 - 1283]
Pages: 9
DOI: 10.2174/138955706778742803
Price: $58

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