Abstract
The pipeline for new antibacterials is bleak despite the fact that infectious diseases account for a quarter of all worldwide deaths due to disease. Bacteria are ideal organisms for a systems biology approach to understanding pathogenesis by combined use of genomic technologies and computer algorithms. This approach can be applied to identify control points in molecular networks, which could be targets for novel drugs.
Keywords: Genomics, systems biology, molecular networks, antibacterials, pathogens
Mini-Reviews in Medicinal Chemistry
Title: Anti-Bacterial Drug Discovery Using Systems Biology
Volume: 6 Issue: 11
Author(s): K. D. Kumble
Affiliation:
Keywords: Genomics, systems biology, molecular networks, antibacterials, pathogens
Abstract: The pipeline for new antibacterials is bleak despite the fact that infectious diseases account for a quarter of all worldwide deaths due to disease. Bacteria are ideal organisms for a systems biology approach to understanding pathogenesis by combined use of genomic technologies and computer algorithms. This approach can be applied to identify control points in molecular networks, which could be targets for novel drugs.
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Kumble D. K., Anti-Bacterial Drug Discovery Using Systems Biology, Mini-Reviews in Medicinal Chemistry 2006; 6 (11) . https://dx.doi.org/10.2174/138955706778742803
DOI https://dx.doi.org/10.2174/138955706778742803 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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