Roles of Nitric Oxide Synthase inhibitor on Antinociceptive Effects of μ-Opioid Agonist in Mice

Title: Roles of Nitric Oxide Synthase inhibitor on Antinociceptive Effects of μ-Opioid Agonist in Mice

Volume: 13 Issue: 10

Author(s): Li-Xiang Chen, Yuan-Ming Qi, Rui Wang, Xin Duan, Yan-Feng Gao and Ding-Jian Yang

Affiliation:

Keywords: Nitric oxide, NG-nitro-L-arginine methyl ester, L-arginine, Analgesia, Endomorphin, Mice

Abstract: In the present study, it was found that intraperitoneal (i.p.) pre-injection of NG-nitro-L-arginine methyl ester (LNAME) significantly influenced the endomorphin-1 (EM-1) and endomorphin-2 (EM-2) induced antinociception. These effects could be inhibited or reversed by L-Arg or naloxone. Our results suggest that the modulatory effect of NO system on the mu-receptor evoked analgesia is different between the two mu receptor subtypes.

Cite this article as:

Chen Li-Xiang, Qi Yuan-Ming, Wang Rui, Duan Xin, Gao Yan-Feng and Yang Ding-Jian, Roles of Nitric Oxide Synthase inhibitor on Antinociceptive Effects of μ-Opioid Agonist in Mice, Protein & Peptide Letters 2006; 13 (10) . https://dx.doi.org/10.2174/092986606778777443