Synthesis and Biochemical Evaluation of a Range of Non-Substituted Phenyl Alkyl Triazole-Based Compounds as Potential Inhibitors of the Enzyme Complex 17α -Hydroxylase/17,20-Lyase (P45017α)

Title: Synthesis and Biochemical Evaluation of a Range of Non-Substituted Phenyl Alkyl Triazole-Based Compounds as Potential Inhibitors of the Enzyme Complex 17α -Hydroxylase/17,20-Lyase (P45017α)

Volume: 3 Issue: 10

Author(s): Caroline P. Owen, Chirag H. Patel, Sachin Dhanani and Sabbir Ahmed

Affiliation:

Keywords: 17α-Hydroxylase, 17, 20-Lyase, P45017α, Synthesis, Evaluation, Triazole

Abstract: We report the synthesis and evaluation of a range of triazole-based inhibitors of the two components of 17α-hydroxylase/17,20-lyase (P45017α). The results show that the compounds were poor inhibitors of 17α- OHase in comparison to lyase; they are therefore good lead compounds in the search for selective inhibitors of P45017α.

Cite this article as:

P. Owen Caroline, H. Patel Chirag, Dhanani Sachin and Ahmed Sabbir, Synthesis and Biochemical Evaluation of a Range of Non-Substituted Phenyl Alkyl Triazole-Based Compounds as Potential Inhibitors of the Enzyme Complex 17α -Hydroxylase/17,20-Lyase (P45017α), Letters in Drug Design & Discovery 2006; 3 (10) . https://dx.doi.org/10.2174/157018006778631857