Abstract
Phosphatidylinositol 3-kinase (PI3K) and serine/threonine protein kinase B (PKB or Akt) pathways regulate important cellular processes and are related to a number of human pathologies, such as cancer. The development of kinase inhibitors, with particular attention to small molecule analogues of natural phosphoinositides for pathway interruption and therapeutic applications will be reviewed.
Keywords: Kinases, Akt, PI3K, cancer, kinase inhibitors, allosteric inhibitors, phosphatidylinositol, phosphatidylinositol analogues
Mini-Reviews in Medicinal Chemistry
Title: Synthesis and Biological Activity of Akt/PI3K Inhibitors
Volume: 6 Issue: 10
Author(s): C. Redaelli, F. Granucci, L. De Gioia and L. Cipolla
Affiliation:
Keywords: Kinases, Akt, PI3K, cancer, kinase inhibitors, allosteric inhibitors, phosphatidylinositol, phosphatidylinositol analogues
Abstract: Phosphatidylinositol 3-kinase (PI3K) and serine/threonine protein kinase B (PKB or Akt) pathways regulate important cellular processes and are related to a number of human pathologies, such as cancer. The development of kinase inhibitors, with particular attention to small molecule analogues of natural phosphoinositides for pathway interruption and therapeutic applications will be reviewed.
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Cite this article as:
Redaelli C., Granucci F., De Gioia L. and Cipolla L., Synthesis and Biological Activity of Akt/PI3K Inhibitors, Mini-Reviews in Medicinal Chemistry 2006; 6 (10) . https://dx.doi.org/10.2174/138955706778560139
DOI https://dx.doi.org/10.2174/138955706778560139 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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