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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Recombinant Factor VIIA, its Clinical Properties, and the Tissue Factor Pathway of Coagulation

Author(s): Timothy J. Bosinski and Ali A. El Solh

Volume 6, Issue 10, 2006

Page: [1111 - 1117] Pages: 7

DOI: 10.2174/138955706778560201

Price: $65

Abstract

Recombinant factor VIIa (rFVIIa) is a synthetic coagulation protease that is structurally similar to humanderived plasma FVIIa. Pharmacologic doses of rFVIIa have been shown to enhance thrombin generation and assist in forming stable fibrin plugs at the site of injury. Recombinant factor VIIa appears to emerge as a valuable treatment alternative for the treatment of bleeding episodes and for achieving hemostasis post surgery in those with bleeding disorders.

Keywords: Recombinant factor VIIa, tissue factor, hemostasis, coagulation


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