Abstract
Recombinant factor VIIa (rFVIIa) is a synthetic coagulation protease that is structurally similar to humanderived plasma FVIIa. Pharmacologic doses of rFVIIa have been shown to enhance thrombin generation and assist in forming stable fibrin plugs at the site of injury. Recombinant factor VIIa appears to emerge as a valuable treatment alternative for the treatment of bleeding episodes and for achieving hemostasis post surgery in those with bleeding disorders.
Keywords: Recombinant factor VIIa, tissue factor, hemostasis, coagulation
Mini-Reviews in Medicinal Chemistry
Title: Recombinant Factor VIIA, its Clinical Properties, and the Tissue Factor Pathway of Coagulation
Volume: 6 Issue: 10
Author(s): Timothy J. Bosinski and Ali A. El Solh
Affiliation:
Keywords: Recombinant factor VIIa, tissue factor, hemostasis, coagulation
Abstract: Recombinant factor VIIa (rFVIIa) is a synthetic coagulation protease that is structurally similar to humanderived plasma FVIIa. Pharmacologic doses of rFVIIa have been shown to enhance thrombin generation and assist in forming stable fibrin plugs at the site of injury. Recombinant factor VIIa appears to emerge as a valuable treatment alternative for the treatment of bleeding episodes and for achieving hemostasis post surgery in those with bleeding disorders.
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Cite this article as:
J. Bosinski Timothy and A. El Solh Ali, Recombinant Factor VIIA, its Clinical Properties, and the Tissue Factor Pathway of Coagulation, Mini-Reviews in Medicinal Chemistry 2006; 6 (10) . https://dx.doi.org/10.2174/138955706778560201
DOI https://dx.doi.org/10.2174/138955706778560201 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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