Abstract
Amyloid β-protein (Aβ) plays a pivotal role in Alzheimers disease (AD). Therapeutic strategies inhibiting Aβ aggregation and promoting extracellular Aβ removal are currently advocated. Here, we review recent literature on intracellular Aβ, especially intranuclear Aβ, and its associated molecules. We also discuss alternative therapeutic strategies to inhibit intracellular Aβ-related pathogenesis.
Keywords: Alzheimer's disease, amyloid β-protein, intracellular, intranuclear, Aβ-related Death Inducing Protein, p53, promoter, apoptosis, amyloid -protein, related Death Inducing Protein
Mini-Reviews in Medicinal Chemistry
Title: Intracellular Amyloid β-Protein and Its Associated Molecules in the Pathogenesis of Alzheimers Disease
Volume: 6 Issue: 10
Author(s): Yasumasa Ohyagi and Takeshi Tabira
Affiliation:
Keywords: Alzheimer's disease, amyloid β-protein, intracellular, intranuclear, Aβ-related Death Inducing Protein, p53, promoter, apoptosis, amyloid -protein, related Death Inducing Protein
Abstract: Amyloid β-protein (Aβ) plays a pivotal role in Alzheimers disease (AD). Therapeutic strategies inhibiting Aβ aggregation and promoting extracellular Aβ removal are currently advocated. Here, we review recent literature on intracellular Aβ, especially intranuclear Aβ, and its associated molecules. We also discuss alternative therapeutic strategies to inhibit intracellular Aβ-related pathogenesis.
Export Options
About this article
Cite this article as:
Ohyagi Yasumasa and Tabira Takeshi, Intracellular Amyloid β-Protein and Its Associated Molecules in the Pathogenesis of Alzheimers Disease, Mini-Reviews in Medicinal Chemistry 2006; 6 (10) . https://dx.doi.org/10.2174/138955706778560175
DOI https://dx.doi.org/10.2174/138955706778560175 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
Call for Papers in Thematic Issues
Bioprospecting of Natural Products as Sources of New Multitarget Therapies
According to the Convention on Biological Diversity, bioprospecting is the exploration of biodiversity and indigenous knowledge to develop commercially valuable products for pharmaceutical and other applications. Bioprospecting involves searching for useful organic compounds in plants, fungi, marine organisms, and microorganisms. Natural products traditionally constituted the primary source of more than ...read more
Computational Frontiers in Medicinal Chemistry
The thematic issue "Computational Frontiers in Medicinal Chemistry" provides a robust platform for delving into state-of-the-art computational methodologies and technologies that significantly propel advancements in medicinal chemistry. This edition seeks to amalgamate top-tier reviews spotlighting the latest trends and breakthroughs in the fusion of computational approaches, including artificial intelligence (AI) ...read more
Mitochondria as a Therapeutic Target in Metabolic Disorders
Mitochondria are the primary site of adenosine triphosphate (ATP) production in mammalian cells. Moreover, these organelles are an important source of reactive oxygen and nitrogen species in virtually any nucleated cell type. The modulation of a myriad of cellular signaling pathways depends on the mitochondrial physiology. Mitochondrial dysfunction is observed ...read more
Natural Products and Dietary Supplements in Alleviation of Metabolic, Cardiovascular, and Neurological Disorders
Metabolic disorders like diabetes, obesity, inflammation, oxidative stress, cancer etc, cardiovascular disorders like angina, myocardial infarction, congestive heart failure etc as well as neurological disorders like Alzheimer?s, Parkinson?s, Epilepsy, Depression, etc are the global burden. They covered the major segment of the diseases and disorders from which the human community ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Gene Therapy and Targeted Toxins for Glioma
Current Gene Therapy Parkinsons Disease: Genetics and Beyond
Current Neuropharmacology Melatonin Could Be Beneficial in SARS-CoV-2 Therapy
The Natural Products Journal Drug Targets from Human Pathogenic Amoebas: Entamoeba histolytica,Acanthamoeba polyphaga and Naegleria fowleri
Infectious Disorders - Drug Targets Emerging Use of Nanotechnology in the Treatment of Neurological Disorders
Current Pharmaceutical Design The Animal Models of Dementia and Alzheimer’s Disease for Pre-Clinical Testing and Clinical Translation
Current Alzheimer Research Role of Lipopolysaccharides in Potential Applications of Nanocarrier Systems
Current Pharmaceutical Design Levamisole-Induced Leukoencephalopathy in Russia: Analysis of 30 Cases
Current Drug Safety Current Status of Anti-HIV Agents
Current Medicinal Chemistry - Anti-Infective Agents Biomedical Consequences of Alcohol Use Disorders in the HIV-Infected Host
Current HIV Research Advances in Metabonomics on Infectious Diseases
Current Metabolomics Basic Approaches in Therapy of Multiple Sclerosis (MS) and Related Diseases: Current Achievement and Prospective
Central Nervous System Agents in Medicinal Chemistry Selective Serotonin-norepinephrine Re-uptake Inhibition Limits Renovas-cular-hypertension Induced Cognitive Impairment, Endothelial Dysfunction, and Oxidative Stress Injury
Current Neurovascular Research Behcets Syndrome: Literature Review
Current Rheumatology Reviews Recent Developments in Particulate-Based Vaccines
Recent Patents on Drug Delivery & Formulation Bioactive N-Phenylimidazole Derivatives
Current Chemical Biology Neurotrophic Factors - A Tool for Therapeutic Strategies in Neurological,Neuropsychiatric and Neuroimmunological Diseases?
Current Medicinal Chemistry Editorial [Hot Topic: The Challenge of Viral Encephalitis: From Etiological Diagnosis to Efficient Antiviral Drug Discovery (Guest Editor: Laurent Dacheux)]
Infectious Disorders - Drug Targets Current and Future Therapies Targeting the Immune System in Multiple Sclerosis
Current Pharmaceutical Biotechnology Understanding Effects of Psychological Stress on Physiology and Disease Through Human Stressome - An Integral Algorithm
Current Bioinformatics