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Current Topics in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Selective Agents for Serotonin2C (5-HT2C) Receptor

Author(s): Enza Lacivita and Marcello Leopoldo

Volume 6, Issue 18, 2006

Page: [1927 - 1970] Pages: 44

DOI: 10.2174/156802606778522168

Price: $65

Abstract

The serotonin2C (5-HT2C) receptor has attracted a lot of attention owing to its role in appetite regulation, depression, obsessive-compulsive disorder (OCD), panic disorders, and substance abuse. This review summarizes nonpatent and patent literature up to November 2005 that deals with the synthesis and characterization of selective 5-HT2C receptor agonists and antagonists. Highlights on structure-activity relationships have been included, when possible.

Keywords: CYP1A2, mCPP, RO600175, anxiolytic, WAY-629, phenylpiperazine


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