Abstract
Apoptosis has been well documented to play a significant role in cell loss during neurodengerative disorders, such as stroke, Parkinson disease, and Alzheimers disease. In addition, reactive oxygen species (ROS) has been implicated in the cellular damage during these neurodegenerative disorders. These ROS can react with cellular macromolecular through oxidation and cause the cells undergo necrosis or apoptosis. The control of the redox environment of the cell provides addition regulation in the signal transduction pathways which are redox sensitive. Recently, many researches focus on the relationship between apoptosis and oxidative stress. However, till now, there is no clear and defined machanisms that how oxidative stress could contribute to the apoptosis. This review hopes to make clear that generation of ROS during brain injury, particularly in ischemic stroke and Alzheimers Disease, and the fact that oxidative state plays a key role in the regulation and control of the cell survival and cell death through its interaction with cellular macromolecules and signal transduction pathway, and ultimately helps in developing an unique therapy for the treatment of these neurodegenerative disorders.
Keywords: Caenorhabditis elegans, extrinsic pathway, apoptosis inducing factor (AIF), Ischemic Stroke, Alzheimer Disease (AD)
Current Alzheimer Research
Title: Oxidative Stress: Apoptosis in Neuronal Injury
Volume: 3 Issue: 4
Author(s): Kok Poh Loh, Shan Hong Huang, Ranil De Silva, Benny K. H. Tan and Yi Zhun Zhu
Affiliation:
Keywords: Caenorhabditis elegans, extrinsic pathway, apoptosis inducing factor (AIF), Ischemic Stroke, Alzheimer Disease (AD)
Abstract: Apoptosis has been well documented to play a significant role in cell loss during neurodengerative disorders, such as stroke, Parkinson disease, and Alzheimers disease. In addition, reactive oxygen species (ROS) has been implicated in the cellular damage during these neurodegenerative disorders. These ROS can react with cellular macromolecular through oxidation and cause the cells undergo necrosis or apoptosis. The control of the redox environment of the cell provides addition regulation in the signal transduction pathways which are redox sensitive. Recently, many researches focus on the relationship between apoptosis and oxidative stress. However, till now, there is no clear and defined machanisms that how oxidative stress could contribute to the apoptosis. This review hopes to make clear that generation of ROS during brain injury, particularly in ischemic stroke and Alzheimers Disease, and the fact that oxidative state plays a key role in the regulation and control of the cell survival and cell death through its interaction with cellular macromolecules and signal transduction pathway, and ultimately helps in developing an unique therapy for the treatment of these neurodegenerative disorders.
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Cite this article as:
Poh Loh Kok, Hong Huang Shan, De Silva Ranil, H. Tan K. Benny and Zhun Zhu Yi, Oxidative Stress: Apoptosis in Neuronal Injury, Current Alzheimer Research 2006; 3 (4) . https://dx.doi.org/10.2174/156720506778249515
DOI https://dx.doi.org/10.2174/156720506778249515 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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