Abstract
Apoptosis is a process that governs the elimination of unwanted, damaged, or infected cells in most organisms. Defects in its execution are associated with several diseases, including cancer. Herein, we discuss novel molecules with potential anti-tumor activity that target components of the apoptotic machinery, specifically Bcl-2 proteins, IAPs and caspases.
Mini-Reviews in Medicinal Chemistry
Title: Anti-tumor Therapeutic Molecules that Target the Programmed Cell Death Machinery
Volume: 6 Issue: 9
Author(s): Iva Ivanovska, Clare N. Muhoro and Pablo M. Irusta
Affiliation:
Keywords: Cancer, apoptosis, IAP, Caspases, Bcl-2
Abstract: Apoptosis is a process that governs the elimination of unwanted, damaged, or infected cells in most organisms. Defects in its execution are associated with several diseases, including cancer. Herein, we discuss novel molecules with potential anti-tumor activity that target components of the apoptotic machinery, specifically Bcl-2 proteins, IAPs and caspases.
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Ivanovska Iva, Muhoro N. Clare and Irusta M. Pablo, Anti-tumor Therapeutic Molecules that Target the Programmed Cell Death Machinery, Mini-Reviews in Medicinal Chemistry 2006; 6 (9) . https://dx.doi.org/10.2174/138955706778195216
DOI https://dx.doi.org/10.2174/138955706778195216 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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