Targeting 5-Lipoxygenase Signaling Pathways to Reverse Drug Resistance in Cancer

Title: Targeting 5-Lipoxygenase Signaling Pathways to Reverse Drug Resistance in Cancer

Volume: 3 Issue: 7

Author(s): Alfonso Catalano and Antonio Procopio

Affiliation:

Keywords: 5-lipoxygenase, Eicosanoids, Cancer therapy, Lipoxygenase inhibitors

Abstract: 5-Lipoxygenase, which leads to the biosynthesis of proinflammatory lipid mediators, is involved in the pathogenesis of cancer. Experimental studies have demonstrated that 5-lipoxygenase inhibitors have antitumoral properties. Here, we describe the compelling evidence that 5-lipoxygenase inhibition is a rational therapy for certain cancers and for adjuvant approaches to cancer therapy.

Cite this article as:

Catalano Alfonso and Procopio Antonio, Targeting 5-Lipoxygenase Signaling Pathways to Reverse Drug Resistance in Cancer, Letters in Drug Design & Discovery 2006; 3 (7) . https://dx.doi.org/10.2174/157018006778194817