Abstract
Malignant gliomas are associated with poor prognoses despite surgical, radiation and chemotherapy interventions. Since notable side-effects are associated with each of the aforementioned therapies, the future design of glioma immunotherapy clinical trials will need to address immune modulation at multiple levels for efficacious results. The review discusses emerging data that provides novel insights into immune modulation and their possible implications for immunotherapeutic approaches. The next generation of immunotherapy is largely focused on improving immune effector targeting and directing the tumor immune microenvironment to work synergistically with systematic immune activation.
Keywords: Microglia, Antigen presenting cells, Glioblastoma multiforme, Dendritic cell, Regulatory T cell, Central nervous system
Letters in Drug Design & Discovery
Title: The Role of Glioma Microenvironment in Immune Modulation: Potential Targets for Intervention
Volume: 3 Issue: 7
Author(s): Mahua Dey, S. Farzana Hussain and Amy B. Heimberger
Affiliation:
Keywords: Microglia, Antigen presenting cells, Glioblastoma multiforme, Dendritic cell, Regulatory T cell, Central nervous system
Abstract: Malignant gliomas are associated with poor prognoses despite surgical, radiation and chemotherapy interventions. Since notable side-effects are associated with each of the aforementioned therapies, the future design of glioma immunotherapy clinical trials will need to address immune modulation at multiple levels for efficacious results. The review discusses emerging data that provides novel insights into immune modulation and their possible implications for immunotherapeutic approaches. The next generation of immunotherapy is largely focused on improving immune effector targeting and directing the tumor immune microenvironment to work synergistically with systematic immune activation.
Export Options
About this article
Cite this article as:
Dey Mahua, Farzana Hussain S. and Heimberger B. Amy, The Role of Glioma Microenvironment in Immune Modulation: Potential Targets for Intervention, Letters in Drug Design & Discovery 2006; 3 (7) . https://dx.doi.org/10.2174/157018006778194844
DOI https://dx.doi.org/10.2174/157018006778194844 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Recent Advancements in Nanodiamond Mediated Brain Targeted Drug
Delivery and Bioimaging of Brain Ailments: A Holistic Review
Pharmaceutical Nanotechnology Oxazole-Based Compounds As Anticancer Agents
Current Medicinal Chemistry Edema-mass Ratio Based On Magnetic Resonance Imaging As A Preoperative Diagnostic Factor For Posterior Fossa Metastasis
Current Medical Imaging Nanoparticle-based Cerebral Drug-Delivery Systems and Antiangiogenic Approach in Gliomas Treatment
Recent Patents on Nanotechnology Novel Beta-Lactam Antibiotics Derivatives: Their New Applications as Gene Reporters, Antitumor Prodrugs and Enzyme Inhibitors
Mini-Reviews in Medicinal Chemistry Ellipticines as DNA-Targeted Chemotherapeutics
Current Medicinal Chemistry Nanofibers: New Insights for Drug Delivery and Tissue Engineering
Current Topics in Medicinal Chemistry Current View on the Mechanism of Action of Perifosine in Cancer
Anti-Cancer Agents in Medicinal Chemistry Persistent Current Blockers of Voltage-Gated Sodium Channels: A Clinical Opportunity for Controlling Metastatic Disease
Recent Patents on Anti-Cancer Drug Discovery Ion Channels and Epilepsy
Current Pharmaceutical Design Ozone Dosage Effect on C6 Cell Growth: in Vitro and in Vivo Tests
Anti-Cancer Agents in Medicinal Chemistry In Vivo Bio-imaging Using Chlorotoxin-based Conjugates
Current Pharmaceutical Design A Review on Chitosan in Drug Delivery for Treatment of Neurological and Psychiatric Disorders
Current Pharmaceutical Biotechnology Saponins in Tumor Therapy
Mini-Reviews in Medicinal Chemistry Role of Osmolytes in Regulating Immune System
Current Pharmaceutical Design 1,2,4-Triazine Analogs as Novel Class of Therapeutic Agents
Mini-Reviews in Medicinal Chemistry Restoring p53 Function in Cancer: Novel Therapeutic Approaches for Applying the Brakes to Tumorigenesis
Recent Patents on Anti-Cancer Drug Discovery Hypericin - A New Antiviral and Antitumor Photosensitizer: Mechanism of Action and Interaction with Biological Macromolecules
Current Drug Targets The Potential Therapeutic Value of Renin-Angiotensin System Inhibitors in the Treatment of Colorectal Cancer
Current Pharmaceutical Design 1,2,3-Triazine Scaffold as a Potent Biologically Active Moiety: A Mini Review
Mini-Reviews in Medicinal Chemistry