Synthesis of C7-Substituted Estra-1,3,5(10),6-Tetraen-3,17 β-Diols

Title: Synthesis of C7-Substituted Estra-1,3,5(10),6-Tetraen-3,17 β-Diols

Volume: 3 Issue: 3

Author(s): Thies Thiemann, G. Ribeiro M. and Maria C. d. Neves Oliveira

Affiliation:

Keywords: thermal dehydration, conjugate addition, steroids, Estranes

Abstract: A series of C7-substituted estra-1,3,5(10),6-tetraene-3,17β-diols were prepared as precursors to radiodiagnostic agents of breast cancer. The introduction of the olefin moiety at C6/C7 in the molecules was achieved through thermal elimination of the 6-hydroxy group in the corresponding estra-1,3,5(10)-triene- 3,17β-diols.

Cite this article as:

Thiemann Thies, M. Ribeiro G. and Neves Oliveira C. d. Maria, Synthesis of C7-Substituted Estra-1,3,5(10),6-Tetraen-3,17 β-Diols, Letters in Organic Chemistry 2006; 3 (3) . https://dx.doi.org/10.2174/157017806775789796