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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Using Hydrochloric Acid- β-Cyclodextrin- Combined Catalysts

Author(s): Genxiang Luo, Chunsheng Liu, Haixia Zhou and Miao He

Volume 3, Issue 3, 2006

Page: [225 - 227] Pages: 3

DOI: 10.2174/157017806775789985

Price: $65

Abstract

An improved approach has been found to carry out the Biginelli reaction for the synthesis of 3,4- dihydropyrimidin- 2(1H)-one derivatives. This synthesis was performed in the presence of hydrochloric acid and β-cyclodextrin in ethanol solution. Compared with the classical Biginelli reaction conditions, this new approach has the advantage of excellent yields and short reaction time.

Keywords: Biginelli reaction, Dihydropyrimidinones, β-cyclodextrin, One-pot, Synthesis


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