Abstract
Passerini reaction involving an oxo component, an isocyanide, and a nucleophile in a single step to prepare α-acyloxy carboxamide, was first discovered by Passerini about 90 years ago. Various modifications of this reaction have already been developed such as Lewis acids catalysis, in situ oxidation of alcohols to aldehydes, in situ oxidation of aldehydes to carboxylic acids, direct alkylative Passerini reaction, etc. The Passerini reaction has developed in organic synthesis, the total synthesis of natural products, synthesis of polycyclics, macrocycles, heterocycles and pharmaceutical industry for the synthesis of drug-like compounds. The Passerini products could be later cyclized by another type of ring-closing reaction. The aim of this review is to provide an overview of synthetic applications of Passerini reaction.
Keywords: Passerini reaction, multicomponent reaction, isocyanide, α-acyloxy carboxamide, heterocycles, multicomponent reactions (MCRs), domino process, α-acyloxy carboxamide moiety, macrocycles, carboxylic acid, N-protected amino acid, aliphatic, aromatic, heteroaromatic carboxylic ester derivatives
Current Organic Chemistry
Title: Synthetic Applications of Passerini Reaction
Volume: 16 Issue: 4
Author(s): Ali Reza Kazemizadeh and Ali Ramazani
Affiliation:
Keywords: Passerini reaction, multicomponent reaction, isocyanide, α-acyloxy carboxamide, heterocycles, multicomponent reactions (MCRs), domino process, α-acyloxy carboxamide moiety, macrocycles, carboxylic acid, N-protected amino acid, aliphatic, aromatic, heteroaromatic carboxylic ester derivatives
Abstract: Passerini reaction involving an oxo component, an isocyanide, and a nucleophile in a single step to prepare α-acyloxy carboxamide, was first discovered by Passerini about 90 years ago. Various modifications of this reaction have already been developed such as Lewis acids catalysis, in situ oxidation of alcohols to aldehydes, in situ oxidation of aldehydes to carboxylic acids, direct alkylative Passerini reaction, etc. The Passerini reaction has developed in organic synthesis, the total synthesis of natural products, synthesis of polycyclics, macrocycles, heterocycles and pharmaceutical industry for the synthesis of drug-like compounds. The Passerini products could be later cyclized by another type of ring-closing reaction. The aim of this review is to provide an overview of synthetic applications of Passerini reaction.
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Cite this article as:
Reza Kazemizadeh Ali and Ramazani Ali, Synthetic Applications of Passerini Reaction, Current Organic Chemistry 2012; 16 (4) . https://dx.doi.org/10.2174/138527212799499868
DOI https://dx.doi.org/10.2174/138527212799499868 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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