Abstract
Transformed cells suffer several changes leading to the increase of protective mechanisms and show a metabolic profile in accordance with higher proliferative capacity. In these mechanisms, changes in mitochondrial activity cause a higher glycolytic metabolism in detriment of oxidative phosphorylation. In these changes, H+-ATPase regulation seems to be importantly involved. During the last years, polyphenols and specially the stilbene resveratrol and related members of its family have been studied because they are able to affect tumour cell growth and cancer progression. Among the different effects induced by resveratrol, inhibition of H+-ATPase seems to be one important mechanism in its effect on cancer progression. Further, an ectopic H+-ATPase located in the outer surface of plasma membrane has been recently involved in cancer progression and angiogenesis. In this article we review the latest findings about resveratrol inhibition of H+-ATPase and its importance in tumour cell growth and cancer progression.
Keywords: Resveratrol, polyphenols, H+-ATPase, mitochondria, angiogenesis, cell growth, transformed cells, glycolytic metabolism, oxidative phosphorylation, cancer progression
Current Pharmaceutical Design
Title: Resveratrol in Cancer: Cellular and Mitochondrial Consequences of Proton Transport Inhibition
Volume: 18 Issue: 10
Author(s): Guillermo Lopez-Lluch, Sara Santa Cruz-Calvo and Placido Navas
Affiliation:
Keywords: Resveratrol, polyphenols, H+-ATPase, mitochondria, angiogenesis, cell growth, transformed cells, glycolytic metabolism, oxidative phosphorylation, cancer progression
Abstract: Transformed cells suffer several changes leading to the increase of protective mechanisms and show a metabolic profile in accordance with higher proliferative capacity. In these mechanisms, changes in mitochondrial activity cause a higher glycolytic metabolism in detriment of oxidative phosphorylation. In these changes, H+-ATPase regulation seems to be importantly involved. During the last years, polyphenols and specially the stilbene resveratrol and related members of its family have been studied because they are able to affect tumour cell growth and cancer progression. Among the different effects induced by resveratrol, inhibition of H+-ATPase seems to be one important mechanism in its effect on cancer progression. Further, an ectopic H+-ATPase located in the outer surface of plasma membrane has been recently involved in cancer progression and angiogenesis. In this article we review the latest findings about resveratrol inhibition of H+-ATPase and its importance in tumour cell growth and cancer progression.
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Cite this article as:
Lopez-Lluch Guillermo, Santa Cruz-Calvo Sara and Navas Placido, Resveratrol in Cancer: Cellular and Mitochondrial Consequences of Proton Transport Inhibition, Current Pharmaceutical Design 2012; 18 (10) . https://dx.doi.org/10.2174/138161212799504849
DOI https://dx.doi.org/10.2174/138161212799504849 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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