Abstract
Tumorigenesis may be affected by various cellular components in the tumor cells and/or by tumor microenvironmental factors. Cytokines, including chemokines (chemotactic cytokines) are polypeptides or small soluble proteins generated by leukocytes and non-leukocytes, including cancer cells and stromal cells, for example, fibroblasts, mesenchymal stem cells (MSCs) and epithelial cells. Cytokines exert their functions on the cells that secrete them, on nearby cells, or on distant cells. Chemokines have expanded beyond their initial roles in impinging on every aspect of the immune system and leukocyte biology. They display multifunctional effects for regulating angiogenesis, tumor cell proliferation and apoptosis, mediating tumor cell metastasis in an organ-specific manner. This review will focus on the structural and functional aspects of chemokines as well as the roles that cytokines and their receptors play in angiogenesis, tumor invasion and metastasis, and discuss their potential value as important therapeutic targets for intervention in cancer.
Keywords: Angiogenesis, chemokines, cytokines, invasion, metastasis, tumorigenesis, microenvironmental factors, polypeptides, stromal cells, tumor cell growth, specific cells, immnue system, transmembrane receptors, cellular transformation, endothelium, cancer-associated fibroblasts, G-protein coupled receptors, inflammation, pathogen infection, T lymphocytes, GDP, GTP, cell invasion, migration, extracellular-regulated kinase
Combinatorial Chemistry & High Throughput Screening
Title: Identification and Functional Study of Cytokines and Chemokines Involved in Tumorigenesis
Volume: 15 Issue: 3
Author(s): Jun Zeng, Ke Xie, Hong Wu, Boya Zhang and Canhua Huang
Affiliation:
Keywords: Angiogenesis, chemokines, cytokines, invasion, metastasis, tumorigenesis, microenvironmental factors, polypeptides, stromal cells, tumor cell growth, specific cells, immnue system, transmembrane receptors, cellular transformation, endothelium, cancer-associated fibroblasts, G-protein coupled receptors, inflammation, pathogen infection, T lymphocytes, GDP, GTP, cell invasion, migration, extracellular-regulated kinase
Abstract: Tumorigenesis may be affected by various cellular components in the tumor cells and/or by tumor microenvironmental factors. Cytokines, including chemokines (chemotactic cytokines) are polypeptides or small soluble proteins generated by leukocytes and non-leukocytes, including cancer cells and stromal cells, for example, fibroblasts, mesenchymal stem cells (MSCs) and epithelial cells. Cytokines exert their functions on the cells that secrete them, on nearby cells, or on distant cells. Chemokines have expanded beyond their initial roles in impinging on every aspect of the immune system and leukocyte biology. They display multifunctional effects for regulating angiogenesis, tumor cell proliferation and apoptosis, mediating tumor cell metastasis in an organ-specific manner. This review will focus on the structural and functional aspects of chemokines as well as the roles that cytokines and their receptors play in angiogenesis, tumor invasion and metastasis, and discuss their potential value as important therapeutic targets for intervention in cancer.
Export Options
About this article
Cite this article as:
Zeng Jun, Xie Ke, Wu Hong, Zhang Boya and Huang Canhua, Identification and Functional Study of Cytokines and Chemokines Involved in Tumorigenesis, Combinatorial Chemistry & High Throughput Screening 2012; 15 (3) . https://dx.doi.org/10.2174/138620712799218608
DOI https://dx.doi.org/10.2174/138620712799218608 |
Print ISSN 1386-2073 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5402 |
Call for Papers in Thematic Issues
Artificial Intelligence Methods for Biomedical, Biochemical and Bioinformatics Problems
Recently, a large number of technologies based on artificial intelligence have been developed and applied to solve a diverse range of problems in the areas of biomedical, biochemical and bioinformatics problems. By utilizing powerful computing resources and massive amounts of data, methods based on artificial intelligence can significantly improve the ...read more
Eco-friendly Agents for Biological Control of Pathogenic Diseases
The discovery of an alternative biological approach to disease management includes work on medicinal products derived from natural sources as a starting point for the development of eco-friendly agents for these diseases and the injuries they cause, as well as reducing human contact with hazardous chemicals and their residues. We ...read more
Emerging trends in diseases mechanisms, noble drug targets and therapeutic strategies: focus on immunological and inflammatory disorders
Recently infectious and inflammatory diseases have been a key concern worldwide due to tremendous morbidity and mortality world Wide. Recent, nCOVID-9 pandemic is a good example for the emerging infectious disease outbreak. The world is facing many emerging and re-emerging diseases out breaks at present however, there is huge lack ...read more
Exploring Spectral Graph Theory in Combinatorial Chemistry
Scope of the Thematic Issue: Combinatorial chemistry involves the synthesis and analysis of a large number of diverse compounds simultaneously. Traditional methods rely on brute force experimentation, which can be time-consuming and resource-intensive. Spectral Graph Theory, a branch of mathematics dealing with the properties of graphs in relation to the ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Anti-Oxidant Gene Therapy by NFkB Decoy Oligodeoxynucleotide
Current Pharmaceutical Biotechnology Apoptosis Signalling Activated by TNF in the Lower Gastrointestinal Tract-Review
Current Pharmaceutical Biotechnology The Role of Tregs in Cancer: Foxp3 as a Putative Target for Therapy
Current Signal Transduction Therapy <i>In silico</i> Analysis of <i>Plasmodium falciparum</i> Actin and Profilin Interaction at the Interface Region for Antimalarial Drug Designing
Letters in Drug Design & Discovery The Use of Vitamin D in Respiratory Diseases
Current Respiratory Medicine Reviews Adiponectin as a Target in Obesity-related Inflammatory State
Endocrine, Metabolic & Immune Disorders - Drug Targets Growth Factors and Astrocytes Metabolism: Possible Roles for Platelet Derived Growth Factor
Medicinal Chemistry Anti-HIV Factors: Targeting Each Step of HIV’s Replication Cycle
Current HIV Research Pharmacological Interference With Protein-protein Interactions of Akinase Anchoring Proteins as a Strategy for the Treatment of Disease
Current Drug Targets Use of Insulin and Insulin Analogs and Risk of Cancer — Systematic Review and Meta-Analysis of Observational Studies
Current Drug Safety The Return of the INGs, Histone Mark Sensors and Phospholipid Signaling Effectors
Current Drug Targets Review of Patents and Commercial Opportunities Involving Mesenchymal Stromal Cells (MSCs) Therapies in Osteoarthritis
Recent Patents on Regenerative Medicine Was Phenserine a Failure or Were Investigators Mislead by Methods?
Current Alzheimer Research Editorial: [Hot Topic: Primary Sjogren’s Syndrome Research and Therapy: Has a New Dawn Arrived?]
Current Pharmaceutical Biotechnology The Role of Eosinophils in Non-Parasitic Infections
Endocrine, Metabolic & Immune Disorders - Drug Targets Stress Hormone-Mediated DNA Damage Response -- Implications for Cellular Senescence and Tumour Progression
Current Drug Targets Omega-3 Fatty Acid Treatment Combined with Chemotherapy to Prevent Toxicity, Drug Resistance, and Metastasis in Cancer
Current Drug Targets Insights into the Pathogenesis of Type 1 Diabetes A Hint for Novel Immunospecific Therapies
Current Molecular Medicine Imatinib Reduces the Vasculogenic Potential of Plastic Tumor Cells
Current Angiogenesis (Discontinued) Thalidomide in Multiple Myeloma
Current Pharmaceutical Biotechnology