Abstract
The cell cycle of primordial germ cells (PGCs), the embryonic precursors of gametes, is characterized by a mitotic phase common to both sexes and a mitotic-meiotic switch in the female. In the present work, we will review the results obtained in the last decade by studies aimed to clarify intrinsic and extrinsic regulatory signals of such processes, with particular reference to mouse PGCs. Besides providing a better understanding of how the gamete population is established in mammals, information about the players controlling the PGC cycle will be useful to clarify other intriguing aspects of germ cell biology such as the origin of germ cell tumours and the mechanisms allowing the maintenance of totipotency in the germ line.
Keywords: Primordial germ cells, cell cycle, gametogenesis, embryonic germ cells, meiosis, mitotic phase, regulatory signals, germ cell tumours, totipotency, germ line
Current Pharmaceutical Design
Title: The Control of Cell Cycle in Mouse Primordial Germ Cells: Old and New Players
Volume: 18 Issue: 3
Author(s): Massimo De Felici and Donatella Farini
Affiliation:
Keywords: Primordial germ cells, cell cycle, gametogenesis, embryonic germ cells, meiosis, mitotic phase, regulatory signals, germ cell tumours, totipotency, germ line
Abstract: The cell cycle of primordial germ cells (PGCs), the embryonic precursors of gametes, is characterized by a mitotic phase common to both sexes and a mitotic-meiotic switch in the female. In the present work, we will review the results obtained in the last decade by studies aimed to clarify intrinsic and extrinsic regulatory signals of such processes, with particular reference to mouse PGCs. Besides providing a better understanding of how the gamete population is established in mammals, information about the players controlling the PGC cycle will be useful to clarify other intriguing aspects of germ cell biology such as the origin of germ cell tumours and the mechanisms allowing the maintenance of totipotency in the germ line.
Export Options
About this article
Cite this article as:
De Felici Massimo and Farini Donatella, The Control of Cell Cycle in Mouse Primordial Germ Cells: Old and New Players, Current Pharmaceutical Design 2012; 18 (3) . https://dx.doi.org/10.2174/138161212799040448
DOI https://dx.doi.org/10.2174/138161212799040448 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
"Tuberculosis Prevention, Diagnosis and Drug Discovery"
The Nobel Prize-winning discoveries of Mycobacterium tuberculosis and streptomycin have enabled an appropriate diagnosis and an effective treatment of tuberculosis (TB). Since then, many newer diagnosis methods and drugs have been saving millions of lives. Despite advances in the past, TB is still a leading cause of infectious disease mortality ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Emerging and re-emerging diseases
Faced with a possible endemic situation of COVID-19, the world has experienced two important phenomena, the emergence of new infectious diseases and/or the resurgence of previously eradicated infectious diseases. Furthermore, the geographic distribution of such diseases has also undergone changes. This context, in turn, may have a strong relationship with ...read more
Melanoma and Non-Melanoma Skin Cancer Treatment: Standard of Care and Recent Advances
In this thematic issue, we aim to provide a standard of care of the diagnosis and treatment of melanoma and non-melanoma skin cancer. The editor will invite authors from different countries who will write review articles of melanoma and non-melanoma skin cancers. The Diagnosis, Staging, Surgical Treatment, Non-Surgical Treatment all ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Quantitative Ultrasound in Diagnosis of Metabolic Bone Diseases
Current Medical Imaging Cardiovascular Biology of Interleukin-6
Current Pharmaceutical Design MicroRNA Regulation of Programmed Cell Death Pathways in Cancer
Current Chemical Biology Targeting the PI3K/Akt/mTOR Axis by Apigenin for Cancer Prevention
Anti-Cancer Agents in Medicinal Chemistry Recent Advances in Regulatory T Cell Therapy of Autoimmunity, Graft Rejection and Cancer
Recent Patents on Inflammation & Allergy Drug Discovery Hemolytic Uremic Syndrome in Children
Current Pediatric Reviews Evaluating Treatment Response of Chronic Myeloid Leukemia: Emerging Science and Technology
Current Cancer Drug Targets Chemometric Evaluation of the Significance of Molecular Structural Descriptors on Binding of Acridinone Derivatives to DNA
Letters in Drug Design & Discovery Implications of FLT3 Mutations in the Therapy of Acute Myeloid Leukemia
Reviews on Recent Clinical Trials Molecular Pathogenesis of Philadelphia-Positive Chronic Myeloid Leukemia – is it all BCR-ABL?
Current Cancer Drug Targets Epigenetic Multiple Modulators
Current Topics in Medicinal Chemistry CDK Inhibitors: From the Bench to Clinical Trials
Current Drug Targets Microarrays as a Tool for Gene Expression Profiling: Application in Ocular and Craniofacial Research
Current Pharmaceutical Analysis Tumour Re-Differentiation Effect of Retinoic Acid: A Novel Therapeutic Approach for Advanced Thyroid Cancer
Current Pharmaceutical Design Immunotherapy for Alzheimers Disease: Rational Basis in Ongoing Clinical Trials
Current Pharmaceutical Design New Insight into P-Glycoprotein as a Drug Target
Anti-Cancer Agents in Medicinal Chemistry Molecular Targeting of Protein Kinases to Optimize Selectivity and Resistance Profiles of Kinase Inhibitors
Current Topics in Medicinal Chemistry Topoisomerase II Inhibitors and Poisons, and the Influence of Cell Cycle Checkpoints
Current Medicinal Chemistry Performance of Feature Selection Methods
Current Genomics Glucocorticoid Receptors and Bone
Current Pharmaceutical Design