Abstract
Tuberculosis (TB) caused by Mycobacterium tuberculosis claims millions of lives each year globally. Although it can be controlled by currently available drug regimen (DOTS), yet the emergence of multidrug resistance (MDR) and extensively drug resistance (XDR) TB is a growing concern. The increasing rate of MDR-TB, co-infection with HIV and XDR-TB necessitates the development of new anti-TB agents that have a practical impact on tuberculosis control. This review article gives a brief introduction of tuberculosis, present day problems, traditional and new anti-TB drug targets, currently used drugs, their mode of action, the pipeline compounds and a short description of new chemical entities (NCEs) as antitubercular agents developed in last 10 years.
Keywords: Antitubercular agents, Arabinogalactan, Chemotherapy, Extensively Drug Resistance (XDR), Fatty acid synthase, MultiDrug Resistance (MDR), Mycobacterium tuberculosis, Mycolic acid, Peptidoglycan, Tuberculosis (TB)
Current Medicinal Chemistry
Title: Developments in Chemical Approaches to Treat Tuberculosis in the Last Decade
Volume: 19 Issue: 4
Author(s): R. P. Tripathi, S. S. Bisht, A. Ajay, A. Sharma, M. Misra and M. Pd. Gupt
Affiliation:
Keywords: Antitubercular agents, Arabinogalactan, Chemotherapy, Extensively Drug Resistance (XDR), Fatty acid synthase, MultiDrug Resistance (MDR), Mycobacterium tuberculosis, Mycolic acid, Peptidoglycan, Tuberculosis (TB)
Abstract: Tuberculosis (TB) caused by Mycobacterium tuberculosis claims millions of lives each year globally. Although it can be controlled by currently available drug regimen (DOTS), yet the emergence of multidrug resistance (MDR) and extensively drug resistance (XDR) TB is a growing concern. The increasing rate of MDR-TB, co-infection with HIV and XDR-TB necessitates the development of new anti-TB agents that have a practical impact on tuberculosis control. This review article gives a brief introduction of tuberculosis, present day problems, traditional and new anti-TB drug targets, currently used drugs, their mode of action, the pipeline compounds and a short description of new chemical entities (NCEs) as antitubercular agents developed in last 10 years.
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Cite this article as:
P. Tripathi R., S. Bisht S., Ajay A., Sharma A., Misra M. and Pd. Gupt M., Developments in Chemical Approaches to Treat Tuberculosis in the Last Decade, Current Medicinal Chemistry 2012; 19 (4) . https://dx.doi.org/10.2174/092986712798918815
DOI https://dx.doi.org/10.2174/092986712798918815 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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