Abstract
Utilizing the intrinsic optical signal (IOS) of retinal Spreading Depression (rSD) waves and the concomitant transparency changes of the tissue, we show that nicotine, in an in vivo near tissue preparation, has neuroprotective effects against the excitotoxic cell death, mediated through the activation of glutamate-receptors. For this study the retinal tissue was treated with NMDA, an agonist for the NMDA-glutamate-receptor, being excitotoxic at higher concentrations, to induce tissue damage. The protective effects of nicotine against glutamate induced neurotoxicity are demonstrated, comparing the IOS with NMDA and NMDA + nicotine. We additionally present data about the decrease of the propagation velocity of rSD waves after nicotine application and show analogical effects obtained with epibatidine, a specific nicotinic acetylcholine receptor (nAChR) agonist.
Keywords: Epibatidine, excitotoxic cell death, neuroprotection, nicotine, NMDA, spreading depression, analogical effects, (nAChR) agonist, neuroprotective effects
Current Medicinal Chemistry
Title: Neuroprotective Properties of Nicotine
Volume: 19 Issue: 2
Author(s): M. Sieber
Affiliation:
Keywords: Epibatidine, excitotoxic cell death, neuroprotection, nicotine, NMDA, spreading depression, analogical effects, (nAChR) agonist, neuroprotective effects
Abstract: Utilizing the intrinsic optical signal (IOS) of retinal Spreading Depression (rSD) waves and the concomitant transparency changes of the tissue, we show that nicotine, in an in vivo near tissue preparation, has neuroprotective effects against the excitotoxic cell death, mediated through the activation of glutamate-receptors. For this study the retinal tissue was treated with NMDA, an agonist for the NMDA-glutamate-receptor, being excitotoxic at higher concentrations, to induce tissue damage. The protective effects of nicotine against glutamate induced neurotoxicity are demonstrated, comparing the IOS with NMDA and NMDA + nicotine. We additionally present data about the decrease of the propagation velocity of rSD waves after nicotine application and show analogical effects obtained with epibatidine, a specific nicotinic acetylcholine receptor (nAChR) agonist.
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Cite this article as:
Sieber M., Neuroprotective Properties of Nicotine, Current Medicinal Chemistry 2012; 19 (2) . https://dx.doi.org/10.2174/092986712803414222
DOI https://dx.doi.org/10.2174/092986712803414222 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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