Abstract
Vitamin D plays a role in a range of functions that may impact on glycaemic control. In this study we systematically report on clinical studies evaluating the impact of vitamin D on aspects of hyperglycaemia in non-pregnant adults. A total of 1,294 articles, of which 417 were reviews, were identified. No well-designed randomised, controlled trials were identified that specifically investigated the effects of vitamin D supplementation on glucose and insulin concentrations. The majority of the studies that are available were poorly designed, having limited numbers, short study duration, or were conducted in volunteers with normal baseline, as measured by 25-hydroxyvitamin D (25(OH)D), concentrations or used inadequate doses of the supplements to normalise vitamin D concentrations, or used inappropriate analyses. Most studies did not observe improvements in glycaemia, with few exceptions. The results were more equivocal for aspects of insulin resistance. Most found no benefit on measures of insulin resistance, although some did. However, more studies described improved insulin release, although data from the studies to date are really inadequate to provide any reliable conclusions. Well-conducted randomised, controlled trials with adequate vitamin D doses are required to effectively assess whether this vitamin can reduce the incidence of diabetes.
Keywords: Calcium, hyperglycaemia, parathyroid hormone, vascular disease, vitamin D, Population, Fibroblast Growth Factor-23, DIABETES, Glucose Metabolism, vascular disease vitamin D
Current Diabetes Reviews
Title: Hyperglycaemia and Vitamin D: A Systematic Overview
Volume: 8 Issue: 1
Author(s): G. Neil Thomas, R. Scragg, Chao Q. Jiang, Will Chan, Winfried Marz, Stefan Pilz, Hyeon C. Kim, Brian Tomlinson, Jos Bosch, Tai H. Lam, Bernard M.Y. Cheung and Kar K. Cheng
Affiliation:
Keywords: Calcium, hyperglycaemia, parathyroid hormone, vascular disease, vitamin D, Population, Fibroblast Growth Factor-23, DIABETES, Glucose Metabolism, vascular disease vitamin D
Abstract: Vitamin D plays a role in a range of functions that may impact on glycaemic control. In this study we systematically report on clinical studies evaluating the impact of vitamin D on aspects of hyperglycaemia in non-pregnant adults. A total of 1,294 articles, of which 417 were reviews, were identified. No well-designed randomised, controlled trials were identified that specifically investigated the effects of vitamin D supplementation on glucose and insulin concentrations. The majority of the studies that are available were poorly designed, having limited numbers, short study duration, or were conducted in volunteers with normal baseline, as measured by 25-hydroxyvitamin D (25(OH)D), concentrations or used inadequate doses of the supplements to normalise vitamin D concentrations, or used inappropriate analyses. Most studies did not observe improvements in glycaemia, with few exceptions. The results were more equivocal for aspects of insulin resistance. Most found no benefit on measures of insulin resistance, although some did. However, more studies described improved insulin release, although data from the studies to date are really inadequate to provide any reliable conclusions. Well-conducted randomised, controlled trials with adequate vitamin D doses are required to effectively assess whether this vitamin can reduce the incidence of diabetes.
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Cite this article as:
Neil Thomas G., Scragg R., Q. Jiang Chao, Chan Will, Marz Winfried, Pilz Stefan, C. Kim Hyeon, Tomlinson Brian, Bosch Jos, H. Lam Tai, M.Y. Cheung Bernard and K. Cheng Kar, Hyperglycaemia and Vitamin D: A Systematic Overview, Current Diabetes Reviews 2012; 8 (1) . https://dx.doi.org/10.2174/157339912798829223
DOI https://dx.doi.org/10.2174/157339912798829223 |
Print ISSN 1573-3998 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6417 |
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