Basal Breast Cancer: A Complex and Deadly Molecular Subtype

F.      Bertucci; P.      Finetti; D.      Birnbaum

Abstract

During the last decade, gene expression profiling of breast cancer has revealed the existence of five molecular subtypes and allowed the establishment of a new classification. The basal subtype, which represents 15-25% of cases, is characterized by an expression profile similar to that of myoepithelial normal mammary cells. Basal tumors are frequently assimilated to triple-negative (TN) breast cancers. They display epidemiological and clinico-pathological features distinct from other subtypes. Their pattern of relapse is characterized by frequent and early relapses and visceral locations. Despite a relative sensitivity to chemotherapy, the prognosis is poor. Recent characterization of their molecular features, such as the dysfunction of the BRCA1 pathway or the frequent expression of EGFR, provides opportunities for optimizing the systemic treatment. Several clinical trials dedicated to basal or TN tumors are testing cytotoxic agents and/or molecularly targeted therapies. This review summarizes the current state of knowledge of this aggressive and hard-to-treat subtype of breast cancer.

Keywords: Basal breast cancer, DNA microarrays, prognosis, triple-negative, phenotype, heterogeneous disease, gene expression, taxonomy, basal tumors, genomics, chemotherapy, cytokeratins, P-cadherin, caveolin 1, claudin genes