Green Synthesis of Tetrahydrobenzo[b]Pyrans by Microwave Assisted Multi-Component One-Pot Reactions in PEG-400

Title: Green Synthesis of Tetrahydrobenzo[b]Pyrans by Microwave Assisted Multi-Component One-Pot Reactions in PEG-400

Volume: 15 Issue: 1

Author(s): Chun Feng, Qiuyan Wang, Cuifen Lu, Guichun Yang and Zuxing Chen

Affiliation:

Keywords: Microwave assisted, multi-component, one-pot reaction, PEG-400, Tetrahydrobenzo[b]pyrans, Polyethylene glycol, nontoxic, recyclable reaction, green synthetic strategy, solvent-free syntheses, organic reactions, pharmacological properties

Abstract: Polyethylene glycol is found to be a nontoxic and recyclable reaction medium for the microwave-assisted, multi-component one-pot reactions of aromatic aldehydes with ethyl-2-cyanoacetate and 1,3-cyclohexanedione or 5,5- dimethyl-1,3-cyclohexanedione in the presence of piperidine. This environmentally friendly microwave protocol offers ease of operation and enables recyclability of reaction medium and synthesis of a variety of substituted tetrahydrobenzo[b]pyran derivatives. It is an efficient, promising, and green synthetic strategy to construct tetrahydrobenzo[b]pyran skeleton.

Cite this article as:

Feng Chun, Wang Qiuyan, Lu Cuifen, Yang Guichun and Chen Zuxing, Green Synthesis of Tetrahydrobenzo[b]Pyrans by Microwave Assisted Multi-Component One-Pot Reactions in PEG-400, Combinatorial Chemistry & High Throughput Screening 2012; 15 (1) . https://dx.doi.org/10.2174/138620712798280790