Abstract
Plasmid DNA (pDNA)-based gene therapy is a promising strategy for treating many chronic diseases and pathological states. Using pDNA has several advantages such as the sustained synthesis of proteins and peptides in their natives form, ease of the combined use of two or more bioactive factors, and cost-effectiveness. For effective pDNA delivery, cationic polymers are good candidates providing high pDNAstability and functionality.In this article, the development of polyplex nanomicelles composed of poly(ethyleneglycol) (PEG)-polycation block copolymers and pDNA as well as their future prospects is reviewed. The issues of safety and the transfection efficiency are highlighted for considerations of in vivo pDNA delivery.
Keywords: Gene therapy, Polyplexnanomicelle, Polycation, Biocompatibility, Toxicity, Non-viral gene delivery, Plasmid DNA, chronic diseases, pathological states, polymers
Current Gene Therapy
Title: Progress and Prospects of Polyplex Nanomicelles for Plasmid DNA Delivery
Volume: 11 Issue: 6
Author(s): Keiji Itaka and Kazunori Kataoka
Affiliation:
Keywords: Gene therapy, Polyplexnanomicelle, Polycation, Biocompatibility, Toxicity, Non-viral gene delivery, Plasmid DNA, chronic diseases, pathological states, polymers
Abstract: Plasmid DNA (pDNA)-based gene therapy is a promising strategy for treating many chronic diseases and pathological states. Using pDNA has several advantages such as the sustained synthesis of proteins and peptides in their natives form, ease of the combined use of two or more bioactive factors, and cost-effectiveness. For effective pDNA delivery, cationic polymers are good candidates providing high pDNAstability and functionality.In this article, the development of polyplex nanomicelles composed of poly(ethyleneglycol) (PEG)-polycation block copolymers and pDNA as well as their future prospects is reviewed. The issues of safety and the transfection efficiency are highlighted for considerations of in vivo pDNA delivery.
Export Options
About this article
Cite this article as:
Itaka Keiji and Kataoka Kazunori, Progress and Prospects of Polyplex Nanomicelles for Plasmid DNA Delivery, Current Gene Therapy 2011; 11 (6) . https://dx.doi.org/10.2174/156652311798192879
DOI https://dx.doi.org/10.2174/156652311798192879 |
Print ISSN 1566-5232 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5631 |
Call for Papers in Thematic Issues
Programmed Cell Death Genes in Oncology: Pioneering Therapeutic and Diagnostic Frontiers (BMS-CGT-2024-HT-45)
Programmed Cell Death (PCD) is recognized as a pivotal biological mechanism with far-reaching effects in the realm of cancer therapy. This complex process encompasses a variety of cell death modalities, including apoptosis, autophagic cell death, pyroptosis, and ferroptosis, each of which contributes to the intricate landscape of cancer development and ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Sexual Dysfunction, Cardiovascular Risk and Effects of Pharmacotherapy
Current Vascular Pharmacology Patent Selections:
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Molecular Determinants of Vascular Calcification: A Bench to Bedside View
Current Molecular Medicine Neurotoxins: Free Radical Mechanisms and Melatonin Protection
Current Neuropharmacology Retinal Imaging: A New Tool for Studying Underlying Liability to Cardiovascular Disease in Schizophrenia
Current Psychiatry Reviews A Focus on Heme Oxygenase-1 (HO-1) Inhibitors
Current Medicinal Chemistry Biomarkers in Systemic Sclerosis-Related Pulmonary Arterial Hypertension
Current Vascular Pharmacology An Update on the Cardiovascular Effects of Quercetin, a Plant Flavonoid
Current Nutrition & Food Science Tailored Angiogenesis Inhibition in Cancer Therapy: Respecting the Heart to Improve the Net Outcome
Current Signal Transduction Therapy Interrelationship between Chronic Kidney Disease and Risk of Cardiovascular Diseases
Cardiovascular & Hematological Agents in Medicinal Chemistry Should Cushing's Syndrome be Considered as a Disease with High Cardiovascular Risk in Relevant Guidelines?
Current Vascular Pharmacology Effects of Obesity Induced by High-Fat Diet on the Pharmacokinetics of Atazanavir in Rats
Drug Metabolism Letters Renal COX-2, Cytokines and 20-HETE: Tubular and Vascular Mechanisms
Current Pharmaceutical Design Disease Outcome, Alexithymia and Depression are Differently Associated with Serum IL-18 Levels in Acute Stroke
Current Neurovascular Research Inflammatory Biomarkers in Atrial Fibrillation
Current Medicinal Chemistry Enhancement of Dissolution Rate of Furosemide Using a Solid Dispersion with D-Glucosamine HCl
Current Pharmaceutical Analysis Editorial from Editor-in-Chief: Amniotic Pulmonary Embolism and the Respiratory System: Management Trends and Future Options
Current Respiratory Medicine Reviews Age Related Macular Degeneration and Visual Disability
Current Drug Targets ATP-Sensitive K+ Channel Openers: Old Drugs with New Clinical Benefits for the Heart
Current Vascular Pharmacology The Honolulu-Asia Aging Study: Epidemiologic and Neuropathologic Research on Cognitive Impairment
Current Alzheimer Research