Serotonin and its Receptors in the Human CNS with New Findings - A Mini Review

A.      S.M. Hung; T.      Y.M. Tsui; J.      C.Y. Lam; M.      S.M. Wai; W.      M. Chan; D.      T. Yew

Abstract

Serotonin (5-hydroxytryptamine, 5-HT) is well known to be closely associated with emotional disorders, such as depression and schizophrenia. The seven main members of 5-HT receptor family including the different subtypes are involved in the functional pathways in the brain and their balance in activity helps to maintain the normal mental stability. As any detrimental changes in the 5-HT system is believed to alter emotion in human, different drugs including serotonin reuptake inhibitors (SSRIs) are nowadays commonly used as anti- depressives. In this review, 5-HT1A and 5-HT2A receptors and serotonergic positive cells in the human were highlighted in particular. It is hoped that this review will give a map of these major 5-HT receptors and serotonergic neurons in the human CNS to facilitate further deciphering of their functions.

Keywords: Serotonin, serotonin receptors, seven subtypes, 5HT1A, 5HT2A, human, animal, brainstem, cerebellum, cortex