Abstract
A genetic component of diabetes and its complications (including diabetic nephropathy (DN)) is obvious, but the causative genes and mechanisms have not yet been satisfactorily identified. Oxidative stress is a single mechanism relating all major pathways responsible for diabetic damage. Numerous oxidative stress-related genes are positional candidates (determined by GWAS) and candidate genes studies confirm the association of their polymorphisms with DN. We present here their overview and connection to the “new antioxidant” therapy principle.
Keywords: Catalase, diabetic nephropathy, glutathione S-transferase, haptoglobin, NADPH oxidase, nitric oxide synthase, oxidative stress, paraoxonase, superoxide dismutase, uncoupling protein, diabetes, gene therapy, candidate genes
Cardiovascular & Hematological Agents in Medicinal Chemistry
Title: A Review of Oxidative Stress Related Genes and New Antioxidant Therapy in Diabetic Nephropathy
Volume: 9 Issue: 4
Author(s): Jana Makuc and Danijel Petrovic
Affiliation:
Keywords: Catalase, diabetic nephropathy, glutathione S-transferase, haptoglobin, NADPH oxidase, nitric oxide synthase, oxidative stress, paraoxonase, superoxide dismutase, uncoupling protein, diabetes, gene therapy, candidate genes
Abstract: A genetic component of diabetes and its complications (including diabetic nephropathy (DN)) is obvious, but the causative genes and mechanisms have not yet been satisfactorily identified. Oxidative stress is a single mechanism relating all major pathways responsible for diabetic damage. Numerous oxidative stress-related genes are positional candidates (determined by GWAS) and candidate genes studies confirm the association of their polymorphisms with DN. We present here their overview and connection to the “new antioxidant” therapy principle.
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Makuc Jana and Petrovic Danijel, A Review of Oxidative Stress Related Genes and New Antioxidant Therapy in Diabetic Nephropathy, Cardiovascular & Hematological Agents in Medicinal Chemistry 2011; 9 (4) . https://dx.doi.org/10.2174/187152511798120949
DOI https://dx.doi.org/10.2174/187152511798120949 |
Print ISSN 1871-5257 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6182 |
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Diabetes and hypertension are real scourges of the 21st century. It is imperative to act in order to find innovative solutions to this problem. Taking medications such as hypoglycemic and antihypertensive drugs may aggravate certain underlying comorbidities, such as chronic kidney disease and cardiovascular disease. This significant drawback therefore requires ...read more
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