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Current Organic Chemistry

Editor-in-Chief

ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Thiourea-Catalyzed Asymmetric Mannich-Type Reactions

Author(s): Bo Han, Jun-Long Li, You-Cai Xiao, Si-Li Zhou and Ying-Chun Chen

Volume 15, Issue 24, 2011

Page: [4128 - 4143] Pages: 16

DOI: 10.2174/138527211798109204

Price: $65

Abstract

Asymmetric Mannich-type reactions are important organic transformations that provide excellent protocols for the synthesis of optically active nitrogen-containing compounds. This article provides an overview on the development of thiourea-catalyzed asymmetric Mannich or nitro-Mannich reactions including scope, limitations, and applications of different catalytic systems.

Keywords: Thiourea, Mannich-type reaction, asymmetric catalysis, organocatalysis, organocatalytic, organic chemistry, stereoselective catalysis, hydrogen-bonding donors, monothiourea, bis-thiourea, b-amino acids, Lewis basic, Isoquinolines, Wittig Reaction, Nitro-Mannich


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