Abstract
During last decade the field of Organocatalysis emerged as one of the cornerstones of organic asymmetric synthesis. The use of organocatalysis has some advantages such as metal free reactions, environmentally friendly conditions, does not need to use dry solvents or inert atmosphere, avoid the use of protecting groups, etc … For these reasons, several research groups have focused their efforts on the development of new organocatalytic methodologies that render the final products in excellent yields and stereoselectivities. Concretely, the organocatalytic synthesis of 5 and 6 membered heterocycles has attracted much attention. In this review we have the aim to describe the different organocatalytic methodologies developed since in the synthesis of 5 and 6 heterocycles.
Keywords: Organocatalysis, Michael reaction, 3+2 cycloaddition, diels-Alder, domino reaction, heterocylic rings, organic chemistry, Synthesis of Azacycles, Pyrrolidines, Saturated Heterocycles, Nitrogen, addition-cyclization, 1,3-dipolar cycloaddition, nitroaldehydes, homoproline derivatives
Current Organic Chemistry
Title: Enantioselective Organocatalytic Synthesis of 5 and 6 Membered Heterocycles
Volume: 15 Issue: 24
Author(s): Jan Vesely and Ramon Rios
Affiliation:
Keywords: Organocatalysis, Michael reaction, 3+2 cycloaddition, diels-Alder, domino reaction, heterocylic rings, organic chemistry, Synthesis of Azacycles, Pyrrolidines, Saturated Heterocycles, Nitrogen, addition-cyclization, 1,3-dipolar cycloaddition, nitroaldehydes, homoproline derivatives
Abstract: During last decade the field of Organocatalysis emerged as one of the cornerstones of organic asymmetric synthesis. The use of organocatalysis has some advantages such as metal free reactions, environmentally friendly conditions, does not need to use dry solvents or inert atmosphere, avoid the use of protecting groups, etc … For these reasons, several research groups have focused their efforts on the development of new organocatalytic methodologies that render the final products in excellent yields and stereoselectivities. Concretely, the organocatalytic synthesis of 5 and 6 membered heterocycles has attracted much attention. In this review we have the aim to describe the different organocatalytic methodologies developed since in the synthesis of 5 and 6 heterocycles.
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Cite this article as:
Vesely Jan and Rios Ramon, Enantioselective Organocatalytic Synthesis of 5 and 6 Membered Heterocycles, Current Organic Chemistry 2011; 15 (24) . https://dx.doi.org/10.2174/138527211798109213
DOI https://dx.doi.org/10.2174/138527211798109213 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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