Abstract
Since the first in-vitro fertilisation (IVF) birth in 1978, the number of children born by assisted reproductive technologies (ART) continues to increase worldwide. However, the safety issues surrounding these procedures remain controversial, and the long term impact on human health is unknown. There is emerging evidence to indicate that IVF may predispose individuals to increased incidence of obesity, elevated blood pressure, fasting glucose and triglycerides and subclinical hypothyroidism. However, few studies have been conducted to date and the underlying mechanisms are unclear. This review will summarize the existing evidence in animal models and in humans, and will discuss epigenetic alterations, which may link manipulation of the pre-implantation embryo with increased risk of the later development of obesity, insulin resistance, type 2 diabetes and cardiovascular disease in offspring. Since these diseases are the leading cause of mortality and can be delayed or prevented by lifestyle modification, prospective follow up studies in IVF born adults are now urgently required to determine the degree of risks utilizing gold standard measures in human and animal models.
Keywords: In vitro Fertilisation (IVF), Assisted Reproductive Technologies (ART), Diabetes, Cardiovascular Disease, Epigenetic, DNA Methylation, infertility, Preterm birth, DNA methylation reprogramming, Intracytoplasmic sperm injection (ICSI)
Current Diabetes Reviews
Title: Does in vitro Fertilisation Increase Type 2 Diabetes and Cardiovascular Risk?
Volume: 7 Issue: 6
Author(s): Miaoxin Chen, Robert J. Norman and Leonie K. Heilbronn
Affiliation:
Keywords: In vitro Fertilisation (IVF), Assisted Reproductive Technologies (ART), Diabetes, Cardiovascular Disease, Epigenetic, DNA Methylation, infertility, Preterm birth, DNA methylation reprogramming, Intracytoplasmic sperm injection (ICSI)
Abstract: Since the first in-vitro fertilisation (IVF) birth in 1978, the number of children born by assisted reproductive technologies (ART) continues to increase worldwide. However, the safety issues surrounding these procedures remain controversial, and the long term impact on human health is unknown. There is emerging evidence to indicate that IVF may predispose individuals to increased incidence of obesity, elevated blood pressure, fasting glucose and triglycerides and subclinical hypothyroidism. However, few studies have been conducted to date and the underlying mechanisms are unclear. This review will summarize the existing evidence in animal models and in humans, and will discuss epigenetic alterations, which may link manipulation of the pre-implantation embryo with increased risk of the later development of obesity, insulin resistance, type 2 diabetes and cardiovascular disease in offspring. Since these diseases are the leading cause of mortality and can be delayed or prevented by lifestyle modification, prospective follow up studies in IVF born adults are now urgently required to determine the degree of risks utilizing gold standard measures in human and animal models.
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Cite this article as:
Chen Miaoxin, J. Norman Robert and K. Heilbronn Leonie, Does in vitro Fertilisation Increase Type 2 Diabetes and Cardiovascular Risk?, Current Diabetes Reviews 2011; 7 (6) . https://dx.doi.org/10.2174/157339911797579151
DOI https://dx.doi.org/10.2174/157339911797579151 |
Print ISSN 1573-3998 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6417 |
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