Abstract
Impaired diabetic wound healing (WH) constitutes a serious diabetic complication with increased morbidity, mortality and health expenditure. The exact pathogenetic mechanisms have not been fully clarified. A variety of hyperglycemia and oxidative stress related factors, have been proposed, including advanced glycaction end products (AGE). The existing literature data, support the role of AGE in the pathogenesis of diabetic complications, namely micro- and macro- angiopathy which underlie delayed diabetic WH. In addition, a large body of evidence support a direct negative effect of AGE in the WH process by their interference with various components involved in the cascade following skin injury. Endogenously formed or exogenously derived AGE, in a similar manner, affect negatively the WH process in diabetes. It is obvious that further studies are needed to clarify the exact role of AGE in the impaired diabetic WH and offer possible new therapeutic strategies
Keywords: Advanced glycation end products, AGE, Ncarboxymethyllysine (CML), Methylglyoxal (MG), Diabetic wound healing, Oxidative stress, Inflammation, LDL, Diabetic Nephropathy, Diabetic Retinopathy
Current Diabetes Reviews
Title: Glycoxidation and Wound Healing in Diabetes: An Interesting Relationship
Volume: 7 Issue: 6
Author(s): Melpomeni Peppa and Sotirios A. Raptis
Affiliation:
Keywords: Advanced glycation end products, AGE, Ncarboxymethyllysine (CML), Methylglyoxal (MG), Diabetic wound healing, Oxidative stress, Inflammation, LDL, Diabetic Nephropathy, Diabetic Retinopathy
Abstract: Impaired diabetic wound healing (WH) constitutes a serious diabetic complication with increased morbidity, mortality and health expenditure. The exact pathogenetic mechanisms have not been fully clarified. A variety of hyperglycemia and oxidative stress related factors, have been proposed, including advanced glycaction end products (AGE). The existing literature data, support the role of AGE in the pathogenesis of diabetic complications, namely micro- and macro- angiopathy which underlie delayed diabetic WH. In addition, a large body of evidence support a direct negative effect of AGE in the WH process by their interference with various components involved in the cascade following skin injury. Endogenously formed or exogenously derived AGE, in a similar manner, affect negatively the WH process in diabetes. It is obvious that further studies are needed to clarify the exact role of AGE in the impaired diabetic WH and offer possible new therapeutic strategies
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Cite this article as:
Peppa Melpomeni and A. Raptis Sotirios, Glycoxidation and Wound Healing in Diabetes: An Interesting Relationship, Current Diabetes Reviews 2011; 7 (6) . https://dx.doi.org/10.2174/157339911797579188
DOI https://dx.doi.org/10.2174/157339911797579188 |
Print ISSN 1573-3998 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6417 |
Call for Papers in Thematic Issues
Advancing Diabetic Wound Healing: Mechanisms and Interventions
In recent years, diabetic wounds have become a global health concern with the increase in the incidence of diabetes. Diabetic wounds are a kind of chronic and refractory ulcer. It is generally due to the microcirculatory disturbances and the reduced levels of endogenous growth factors. Delayed cutaneous wound healing is ...read more
Oxidative and inflammatory responses in the development of secondary diabetic complications
Diabetes, along with its associated secondary complications, represents a significant global health challenge, contributing significantly to morbidity and mortality. Unhealthy lifestyle habits, reduced physical activity, environmental pollutants, and stress are pivotal factors in the onset of diabetes, particularly type-2 diabetes. Poorly managed hyperglycemia can lead to various complications, including neuropathy, ...read more
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