Abstract
While lifestyle modifications and metformin are the cornerstone of the initial management of type 2 diabetes mellitus, there is an increasing array of second and third-line pharmacological agents for this condition. These include sulphonylureas, insulin, thiazolidinediones and alpha-glucosidase inhibitors, with the more recent addition of glucagon- like peptide-1 agonists, dipeptidyl peptidase-IV inhibitors and pramlintide. Moreover, insulin analogues that better simulate endogenous insulin secretion have been developed. This review aims to provide an update on the current pharmacological management of type 2 diabetes mellitus, and to highlight the benefits and limitations of each treatment.
Keywords: Type 2 diabetes mellitus, Insulin, Thiazolidinediones, Sulphonylurea, Metformin, Glucagon-like peptide-1, Dipeptidyl peptidase-IV inhibitor, Bromocriptine, Alpha glucosidase inhibitor, Colesevelam
Current Diabetes Reviews
Title: Pharmacological Management of Type 2 Diabetes Mellitus: An Update
Volume: 7 Issue: 6
Author(s): Samer El-Kaissi and Suphia Sherbeeni
Affiliation:
Keywords: Type 2 diabetes mellitus, Insulin, Thiazolidinediones, Sulphonylurea, Metformin, Glucagon-like peptide-1, Dipeptidyl peptidase-IV inhibitor, Bromocriptine, Alpha glucosidase inhibitor, Colesevelam
Abstract: While lifestyle modifications and metformin are the cornerstone of the initial management of type 2 diabetes mellitus, there is an increasing array of second and third-line pharmacological agents for this condition. These include sulphonylureas, insulin, thiazolidinediones and alpha-glucosidase inhibitors, with the more recent addition of glucagon- like peptide-1 agonists, dipeptidyl peptidase-IV inhibitors and pramlintide. Moreover, insulin analogues that better simulate endogenous insulin secretion have been developed. This review aims to provide an update on the current pharmacological management of type 2 diabetes mellitus, and to highlight the benefits and limitations of each treatment.
Export Options
About this article
Cite this article as:
El-Kaissi Samer and Sherbeeni Suphia, Pharmacological Management of Type 2 Diabetes Mellitus: An Update, Current Diabetes Reviews 2011; 7 (6) . https://dx.doi.org/10.2174/157339911797579160
DOI https://dx.doi.org/10.2174/157339911797579160 |
Print ISSN 1573-3998 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6417 |
Call for Papers in Thematic Issues
Advancing Diabetic Wound Healing: Mechanisms and Interventions
In recent years, diabetic wounds have become a global health concern with the increase in the incidence of diabetes. Diabetic wounds are a kind of chronic and refractory ulcer. It is generally due to the microcirculatory disturbances and the reduced levels of endogenous growth factors. Delayed cutaneous wound healing is ...read more
Oxidative and inflammatory responses in the development of secondary diabetic complications
Diabetes, along with its associated secondary complications, represents a significant global health challenge, contributing significantly to morbidity and mortality. Unhealthy lifestyle habits, reduced physical activity, environmental pollutants, and stress are pivotal factors in the onset of diabetes, particularly type-2 diabetes. Poorly managed hyperglycemia can lead to various complications, including neuropathy, ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
COVID-19, Angiotensin-Converting Enzyme 2 and Renin-Angiotensin System
Inhibition: Implications for Practice
Current Hypertension Reviews Synthetic Androgens as Designer Supplements
Current Neuropharmacology Vitamin D Deficiency and Oxidative Stress in Type 2 Diabetic Population of India
Cardiovascular & Hematological Agents in Medicinal Chemistry Hypertension, Cognitive Impairment and Dementia: An Epidemiological Perspective
Current Hypertension Reviews Anthocyanins as a Potential Therapy for Diabetic Retinopathy
Current Medicinal Chemistry Understanding the Molecular and Cellular Changes Behind Aortic Valve Stenosis
Current Pharmaceutical Biotechnology Redefining the Role of Long-Acting Phosphodiesterase Inhibitor Tadalafil in the Treatment of Diabetic Erectile Dysfunction
Current Diabetes Reviews Statins: An Under-Appreciated Asset for the Prevention and the Treatment of NAFLD or NASH and the Related Cardiovascular Risk
Current Vascular Pharmacology Statin Therapy-Evidence Beyond Lipid Lowering Contributing to Plaque Stability
Current Medicinal Chemistry New Developments in the Diagnosis and Management of Resistant Hypertension
Current Medicinal Chemistry Insulin Resistance in the Early Stages of Renal Failure: Implications for Cardiovascular Risk
Current Diabetes Reviews Increased Paternal Age and Child Health and Development
Current Pediatric Reviews Neutrophil-to-lymphocyte Ratio and Platelet-to-lymphocyte Ratio as Biomarkers for Cardiovascular Surgery Procedures: A Literature Review
Reviews on Recent Clinical Trials Inhibitory Smad7: Emerging Roles in Health and Disease
Current Molecular Pharmacology Clearance of Amyloid-β Peptide Across the Blood-Brain Barrier: Implication for Therapies in Alzheimers Disease
CNS & Neurological Disorders - Drug Targets Recent Advances in Management of Diabetic Macular Edema
Current Diabetes Reviews Novel Aspects in the Pathogenesis of Nonalcoholic Steatohepatitis
Current Molecular Medicine A Systematic Review of a Naturally Occurring Iridoid: Catalpol
Current Bioactive Compounds HIV-1 Latency and Eradication: Past, Present and Future
Current HIV Research Withdrawal Notice: Characterization of Glyoxal Modified LDL: Role in the Generation of Circulating Autoantibodies in Type 2 Diabetes Mellitus and Coronary Artery Disease
Current Drug Targets