Abstract
Electrochemical behavior of disopyramide (DPA) on glassy carbon electrode (GCE) was investigated by using cyclic voltammetry, square-wave voltammetry and constant potential bulk electrolysis. Adsorption and diffusion properties of DPA were evaluated. Differential pulse anodic adsorptive stripping voltammetric (DPAAdSV) and squarewave anodic adsorptive stripping voltammetric (SWAAdSV) methods were developed for its direct determination in pharmaceutical preparations and biological samples. Linear working concentration range for both methods was found as 3x10-7 M (0.102 mg/L) - 3x10-6 M (1.0 mg/L). Limit of detection and limit of quantitation for DPAAdSV were found to be 2.9x10-7 M (0.10 mg/L) and 9.5x10-7 M (0.32 mg/L), respectively and they were calculated to be 1.4x10-7 M (0.05 mg/L) and 4.5x10-7 M (0.15 mg/L) for SWAAdSV. Proposed methods were successfully applied to determine the content of DPA in pharmaceutical preparations and biological samples.
Keywords: Disopyramide, Electrochemical behavior, Voltammetric stripping methods, Assay, Glassy carbon electrode, Limit of detection, Limit of quantitation, Pharmaceutical preparations, Biological samples, Validation parameters
Current Pharmaceutical Analysis
Title: Voltammetric Stripping Methods for Direct Determination of Disopyramide
Volume: 8 Issue: 1
Author(s): Muharrem Duran, Zehra Durmus, Ibrahim H. Tasdemir and Esma Kilic
Affiliation:
Keywords: Disopyramide, Electrochemical behavior, Voltammetric stripping methods, Assay, Glassy carbon electrode, Limit of detection, Limit of quantitation, Pharmaceutical preparations, Biological samples, Validation parameters
Abstract: Electrochemical behavior of disopyramide (DPA) on glassy carbon electrode (GCE) was investigated by using cyclic voltammetry, square-wave voltammetry and constant potential bulk electrolysis. Adsorption and diffusion properties of DPA were evaluated. Differential pulse anodic adsorptive stripping voltammetric (DPAAdSV) and squarewave anodic adsorptive stripping voltammetric (SWAAdSV) methods were developed for its direct determination in pharmaceutical preparations and biological samples. Linear working concentration range for both methods was found as 3x10-7 M (0.102 mg/L) - 3x10-6 M (1.0 mg/L). Limit of detection and limit of quantitation for DPAAdSV were found to be 2.9x10-7 M (0.10 mg/L) and 9.5x10-7 M (0.32 mg/L), respectively and they were calculated to be 1.4x10-7 M (0.05 mg/L) and 4.5x10-7 M (0.15 mg/L) for SWAAdSV. Proposed methods were successfully applied to determine the content of DPA in pharmaceutical preparations and biological samples.
Export Options
About this article
Cite this article as:
Duran Muharrem, Durmus Zehra, H. Tasdemir Ibrahim and Kilic Esma, Voltammetric Stripping Methods for Direct Determination of Disopyramide, Current Pharmaceutical Analysis 2012; 8 (1) . https://dx.doi.org/10.2174/157341212798995584
DOI https://dx.doi.org/10.2174/157341212798995584 |
Print ISSN 1573-4129 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-676X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Oxidative Stress and Mitochondrial Impairment After Treatment with Anti-HIV Drugs: Clinical Implications
Current Pharmaceutical Design Endothelial Dysfunction in Diabetes: From Mechanisms to Therapeutic Targets
Current Medicinal Chemistry The Mast Cell: A Potential Therapeutic Target in Myocardial Infarction
Drug Design Reviews - Online (Discontinued) Atenolol: Differences in Mode of Action Compared with other Antihypertensives.An Opportunity to Identify Features that Influence Outcome?
Current Pharmaceutical Design Antithrombotic Treatment in Cardiomyopathies
Current Pharmaceutical Design Clinical Vignettes: Integrated Care of Cancer Patients by Oncologists and Cardiologists
Current Cardiology Reviews ACE2 and Diabetic Complications
Current Pharmaceutical Design The Insular Cortex and Takotsubo Cardiomyopathy
Current Pharmaceutical Design Advanced Glycation End Products: A Link Between Periodontitis and Diabetes Mellitus?
Current Diabetes Reviews Valosin Containing Protein Associated Fronto-Temporal Lobar Degeneration:Clinical Presentation, Pathologic Features and Pathogenesis
Current Alzheimer Research Inflammatory Markers in Cardiovascular Disease; Lessons Learned and Future Perspectives
Current Vascular Pharmacology Role of Secondary Alcohol Metabolites in Anthracycline Cardiotoxicity: from Hypotheses to New Drugs
Drug Design Reviews - Online (Discontinued) Mechanisms of the Beneficial Actions of Ischemic Preconditioning on Subcellular Remodeling in Ischemic-Reperfused Heart
Current Cardiology Reviews Withdrawal Notice: COVID-19: Outbreak to Global
Anti-Infective Agents Atrial Fibrillation: The Emerging Role of Inflammation and Oxidative Stress
Cardiovascular & Hematological Disorders-Drug Targets Atherogenesis in Renal Patients: A Model of Vascular Disease?
Current Vascular Pharmacology Antithrombotic Treatment after Atrial Fibrillation Ablation
Current Pharmaceutical Design Pharmacological Therapy of Pericardial Diseases
Current Pharmaceutical Design Erythropoietin and mTOR: A “One-Two Punch” for Aging-Related Disorders Accompanied by Enhanced Life Expectancy
Current Neurovascular Research Regulation of Inflammation and Myocardial Fibrosis in Experimental Autoimmune Myocarditis
Inflammation & Allergy - Drug Targets (Discontinued)