Abstract
Gene therapy is an emerging technique with widespread applications in treatment of cardiovascular diseases, monogenic disorder, infectious diseases, and especially cancers. The major challenge for gene therapy is to deliver therapeutic genes to target tissues. Although various gene delivery vectors such as harmless viruses and micro/nano-particles have been developed (i.e. commonly system delivery), concerns remain for the transfection efficiency and stability of those working copies in these vectors. Local gene delivery such as intratumoral infusion, electroporation and implants offers significantly enhanced transfection efficiency with decreased toxicity compared to system delivery and has been broadly used in clinics. In this paper, we reviewed the local gene delivery methods and discussed their distinctive advantages and potential challenges in cancer treatment.
Keywords: cancer therapy, drug-eluting implants, electrogene, intratumoral, local gene therapy, magnetic, tumor-tropism delivery, ultrasound, radiotherapy, nano/microparticles
Current Gene Therapy
Title: Local Gene Delivery for Cancer Therapy
Volume: 11 Issue: 5
Author(s): Lili Zhao, Jinhui Wu, He Zhou, Ahu Yuan, Xiang Zhang, Feng Xu and Yiqiao Hu
Affiliation:
Keywords: cancer therapy, drug-eluting implants, electrogene, intratumoral, local gene therapy, magnetic, tumor-tropism delivery, ultrasound, radiotherapy, nano/microparticles
Abstract: Gene therapy is an emerging technique with widespread applications in treatment of cardiovascular diseases, monogenic disorder, infectious diseases, and especially cancers. The major challenge for gene therapy is to deliver therapeutic genes to target tissues. Although various gene delivery vectors such as harmless viruses and micro/nano-particles have been developed (i.e. commonly system delivery), concerns remain for the transfection efficiency and stability of those working copies in these vectors. Local gene delivery such as intratumoral infusion, electroporation and implants offers significantly enhanced transfection efficiency with decreased toxicity compared to system delivery and has been broadly used in clinics. In this paper, we reviewed the local gene delivery methods and discussed their distinctive advantages and potential challenges in cancer treatment.
Export Options
About this article
Cite this article as:
Zhao Lili, Wu Jinhui, Zhou He, Yuan Ahu, Zhang Xiang, Xu Feng and Hu Yiqiao, Local Gene Delivery for Cancer Therapy, Current Gene Therapy 2011; 11 (5) . https://dx.doi.org/10.2174/156652311797415854
DOI https://dx.doi.org/10.2174/156652311797415854 |
Print ISSN 1566-5232 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5631 |
Call for Papers in Thematic Issues
Programmed Cell Death Genes in Oncology: Pioneering Therapeutic and Diagnostic Frontiers (BMS-CGT-2024-HT-45)
Programmed Cell Death (PCD) is recognized as a pivotal biological mechanism with far-reaching effects in the realm of cancer therapy. This complex process encompasses a variety of cell death modalities, including apoptosis, autophagic cell death, pyroptosis, and ferroptosis, each of which contributes to the intricate landscape of cancer development and ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
The Phosphoinositide 3-Kinase Pathway in Human Cancer: Genetic Alterations and Therapeutic Implications
Current Genomics The NK-1 Receptor: A New Target in Cancer Therapy
Current Drug Targets Update on Cancer Related Issues of Mesenchymal Stem Cell-Based Therapies
Current Stem Cell Research & Therapy AAVs Anatomy: Roadmap for Optimizing Vectors for Translational Success
Current Gene Therapy In Vivo Anticancer Activity, Toxicology and Histopathological Studies of the Thiolate Gold(I) Complex [Au(Spyrimidine)(PTA-CH<sub>2</sub>Ph)]Br
Anti-Cancer Agents in Medicinal Chemistry Biomacromolecule-Functionalized Nanoparticle-Based Conjugates for Potentiation of Anticancer Therapy
Current Cancer Drug Targets Xanthone Derivatives: New Insights in Biological Activities
Current Medicinal Chemistry Targeted Therapy Towards Cancer-A Perspective
Anti-Cancer Agents in Medicinal Chemistry Double Edge Sword Behavior of Carbendazim: A Potent Fungicide With Anticancer Therapeutic Properties
Anti-Cancer Agents in Medicinal Chemistry 4-Aminocyclopentane-1,3-diols as Platforms for Diversity: Synthesis of Anandamide Analogs
Medicinal Chemistry Strategies of overcoming the physiological barriers for tumor-targeted nano-sized drug delivery systems
Current Pharmaceutical Design Propolis Extract Regulates microRNA Expression in Glioblastoma and Brain Cancer Stem Cells
Anti-Cancer Agents in Medicinal Chemistry Aflibercept (VEGF-TRAP): The Next Anti-VEGF Drug
Inflammation & Allergy - Drug Targets (Discontinued) Current Developments in Targeted Drug Delivery Systems for Glioma
Current Pharmaceutical Design Oligonucleotides as Anticancer Agents: From the Benchside to the Clinic and Beyond
Current Pharmaceutical Design How is Gene Transfection Able to Improve Current Chemotherapy? The Role of Combined Therapy in Cancer Treatment
Current Medicinal Chemistry A Role for the Inflammatory Mediators Cox-2 and Metalloproteinases in Cancer Stemness
Anti-Cancer Agents in Medicinal Chemistry Computer Modeling of Brain Tumor Growth
Mini-Reviews in Medicinal Chemistry Molecular Cytogenetics and Cytogenomics of Brain Diseases
Current Genomics Radiosensitization Induced by Ultra-stable PVA-coated Gold Nanoparticles: A Study with Fricke Dosimeter, Plasmid DNA and F98 Glioma Cells
Current Nanomedicine