2-Aminoimidazole, Glycociamidine and 2-Thiohydantoin-Marine Alkaloids as Molecular Inspirations for the Development of Lead Structures

Title: 2-Aminoimidazole, Glycociamidine and 2-Thiohydantoin-Marine Alkaloids as Molecular Inspirations for the Development of Lead Structures

Volume: 12 Issue: 11

Author(s): Ravi Kumar, Shahnawaz Khan and Prem M.S. Chauhan

Affiliation:

Keywords: 2-Aminoimidazole alkaloids, anticancer, antihistaminic, antimicrobial, Glycociamidine, 2-Thiohydantoin, drug discovery, Nagelamides, bioactive agents

Abstract: This review provides a detailed account on the biological activities of structurally diverse secondary metabolites from marine sponges having 2-aminoimidazole, glycociamidine and/or 2-thiohydantoin ring functions. This review will complement two previous short reviews which did however not address the potential of these natural products for drug discovery. We will discuss the naturally occurring alkaloids and give an account on their structure activity relationships.

Cite this article as:

Kumar Ravi, Khan Shahnawaz and M.S. Chauhan Prem, 2-Aminoimidazole, Glycociamidine and 2-Thiohydantoin-Marine Alkaloids as Molecular Inspirations for the Development of Lead Structures, Current Drug Targets 2011; 12 (11) . https://dx.doi.org/10.2174/138945011798109428