Hypercholesterolemia: Chemical Aspect of Approach

Title: Hypercholesterolemia: Chemical Aspect of Approach

Volume: 18 Issue: 26

Author(s): N. F. Salakhutdinov, L. N. Rogoza and G. A. Tolstikov

Affiliation:

Keywords: CETP inhibitors, cholesterol-regulating agents, HMG-CoA reductase, inhibitors of intestinal absorption of cholesterol, PPARα and PPARα/γ agonists, regulators LDLR expression, squalene 2, 3-oxide-lanosterol cyclase inhibitors, " structure-activity" relationships

Abstract: This review is the first attempt at systematization and analysis of the literature data (covering the last decade) on the chemical structures and specific activities of cholesterol-regulating agents.

Six of thirty currently known biological targets for treating hyperlipidemia were selected and considered. All of the chemical structures under study are divided into two classes with different mechanisms of their activity: cholesterol biosynthesis blockers (HMG-CoA reductase and squalene 2,3-oxide-lanosterol cyclase inhibitors) and regulators of cholesterol transformations in the organism (PPARα and PPARα/γ agonists, inhibitors of intestinal absorption of cholesterol, cholesteryl ester transfer protein (CETP) inhibitors, and regulators of low-density-lipoprotein receptor (LDLR) expression).

Cite this article as:

Salakhutdinov N. F., Rogoza L. N. and Tolstikov G. A., Hypercholesterolemia: Chemical Aspect of Approach, Current Medicinal Chemistry 2011; 18 (26) . https://dx.doi.org/10.2174/092986711796957248