Abstract
Sialic acids are one of the important constituents of glycoconjugates in the deuterostome lineage of animals and microorganisms. Siglecs (Sialic acid-binding immunoglobulin like lectins) are a family of cell-surface receptor proteins that recognize sialylated glycoconjugates as ligands. To date, 15 Siglecs have been described in humans and are mainly known as regulators of the immune system. Several of the Siglecs are emerging as potential targets for the treatment of some inflammatory, autoimmune, allergic, neurodegenerative and infectious diseases. In addition to antibody mediated therapy, high-affinity ligand-based probes of Siglec receptors would represent invaluable tools to effectively address therapeutic opportunities of Sialic acid-mediated Siglec recognition. This review discusses some aspects of structure and function of Siglec receptors, and concisely summarizes up-to-date progress on the identification of sialic acid based high-affinity ligands of certain well explored Siglec receptors.
Keywords: High-affinity ligands, Immune system, Inhibitor design, Carbohydrates, Sialic acid, Siglec, Immunoglobulin, Glycoconjugates, Sialoadhesin, CD22
Current Medicinal Chemistry
Title: High-Affinity Ligands of Siglec Receptors and their Therapeutic Potentials
Volume: 18 Issue: 23
Author(s): S. Magesh, H. Ando, T. Tsubata, H. Ishida and M. Kiso
Affiliation:
Keywords: High-affinity ligands, Immune system, Inhibitor design, Carbohydrates, Sialic acid, Siglec, Immunoglobulin, Glycoconjugates, Sialoadhesin, CD22
Abstract: Sialic acids are one of the important constituents of glycoconjugates in the deuterostome lineage of animals and microorganisms. Siglecs (Sialic acid-binding immunoglobulin like lectins) are a family of cell-surface receptor proteins that recognize sialylated glycoconjugates as ligands. To date, 15 Siglecs have been described in humans and are mainly known as regulators of the immune system. Several of the Siglecs are emerging as potential targets for the treatment of some inflammatory, autoimmune, allergic, neurodegenerative and infectious diseases. In addition to antibody mediated therapy, high-affinity ligand-based probes of Siglec receptors would represent invaluable tools to effectively address therapeutic opportunities of Sialic acid-mediated Siglec recognition. This review discusses some aspects of structure and function of Siglec receptors, and concisely summarizes up-to-date progress on the identification of sialic acid based high-affinity ligands of certain well explored Siglec receptors.
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Magesh S., Ando H., Tsubata T., Ishida H. and Kiso M., High-Affinity Ligands of Siglec Receptors and their Therapeutic Potentials, Current Medicinal Chemistry 2011; 18 (23) . https://dx.doi.org/10.2174/092986711796642580
DOI https://dx.doi.org/10.2174/092986711796642580 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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