Abstract
Tri-substituted oxazoles, appearing in several anticancer natural products and various other bioactive compounds, have become increasingly visible in recent years. Research into the synthesis of such oxazoles has led to the development of new synthetic methods as well as refinements of classic methods of their synthesis. In addition, a number of research groups have pursued the synthesis of fully-functionalized-oxazole-containing natural products. We review recent investigations (2004-present) into methods of tri-substituted oxazole synthesis, and the construction of complex natural products containing such oxazoles.
Keywords: Methodology, natural product, tri-substituted oxazole, heterocycles, review, total synthesis, drug discovery, Tri-substituted oxazoles, Nitrogenous heterocycles, myriad, Telomestatin, anticancer activities, Martefragin A, Siphonazole
Current Organic Chemistry
Title: Recent Advances in the Assembly of Tri-substituted Oxazoles
Volume: 15 Issue: 16
Author(s): Charles Dylan Turner and Huan Steven Liang
Affiliation:
Keywords: Methodology, natural product, tri-substituted oxazole, heterocycles, review, total synthesis, drug discovery, Tri-substituted oxazoles, Nitrogenous heterocycles, myriad, Telomestatin, anticancer activities, Martefragin A, Siphonazole
Abstract: Tri-substituted oxazoles, appearing in several anticancer natural products and various other bioactive compounds, have become increasingly visible in recent years. Research into the synthesis of such oxazoles has led to the development of new synthetic methods as well as refinements of classic methods of their synthesis. In addition, a number of research groups have pursued the synthesis of fully-functionalized-oxazole-containing natural products. We review recent investigations (2004-present) into methods of tri-substituted oxazole synthesis, and the construction of complex natural products containing such oxazoles.
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Cite this article as:
Dylan Turner Charles and Steven Liang Huan, Recent Advances in the Assembly of Tri-substituted Oxazoles, Current Organic Chemistry 2011; 15 (16) . https://dx.doi.org/10.2174/138527211796378442
DOI https://dx.doi.org/10.2174/138527211796378442 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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