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Current Organic Chemistry

Editor-in-Chief

ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Recent Advances in the Assembly of Tri-substituted Oxazoles

Author(s): Charles Dylan Turner and Huan Steven Liang

Volume 15, Issue 16, 2011

Page: [2846 - 2870] Pages: 25

DOI: 10.2174/138527211796378442

Price: $65

Abstract

Tri-substituted oxazoles, appearing in several anticancer natural products and various other bioactive compounds, have become increasingly visible in recent years. Research into the synthesis of such oxazoles has led to the development of new synthetic methods as well as refinements of classic methods of their synthesis. In addition, a number of research groups have pursued the synthesis of fully-functionalized-oxazole-containing natural products. We review recent investigations (2004-present) into methods of tri-substituted oxazole synthesis, and the construction of complex natural products containing such oxazoles.

Keywords: Methodology, natural product, tri-substituted oxazole, heterocycles, review, total synthesis, drug discovery, Tri-substituted oxazoles, Nitrogenous heterocycles, myriad, Telomestatin, anticancer activities, Martefragin A, Siphonazole


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