Abstract
Evidence accumulates that a family of plant compounds, known as flavonoids, can prevent or slow down the progression of cardiovascular diseases, cancer, inflammatory and neurodegenerative diseases. Flavonoids are considered beneficial, this is often attributed to their powerful antioxidant properties. In this role, certain types of flavonoids are considered to be far more powerful than the two most common antioxidants, vitamin C and vitamin E, at preventing cellular damage brought on by free radicals. Interestingly, flavonoids exert those activities not only through direct radical scavenging, but also through regulating nitric oxide, and chelating metals. In addition, flavonoids are thought to facilitate/promote other important biological processes, resulting in modulation of enzymes, a decrease in leukocyte immobilization, inhibition of cell proliferation and angiogenesis, and effects on signaling pathways. The results of in vitro studies have demonstrated that the antioxidative property of flavonoids is unambiguous; however it is still not supported by strong consistent evidence in vivo. Therefore, the antioxidant theory as a mechanism of action of flavonoids is controversial. As a result, flavonoids are hypothesized to exert their activities partly through cell signaling pathways. This review intends to acquaint the reader with different pathways in which flavonoids function or might function. Furthermore, we will provide insight into the beneficial health effects of these substances.
Keywords: Anti-inflammatory, Antioxidant, Bioavailability, Cardiovascular disease, Flavonoids, Nutrition, Pro-oxidant, Signaling pathways, coronary heart disease (CHD), lowdensity lipoprotein, anti-carcinogenic processes, anthocyanidins, quercetin, kaempferol, myricetin
Current Organic Chemistry
Title: Antioxidative Properties of Flavonoids
Volume: 15 Issue: 15
Author(s): Thomas C.F. Bodewes, Joanna Luttikhold, Mireille F.M. van Stijn, Marliek Visser, Klaske van Norren, Mechteld A.R. Vermeulen and Paul A.M. van Leeuwen
Affiliation:
Keywords: Anti-inflammatory, Antioxidant, Bioavailability, Cardiovascular disease, Flavonoids, Nutrition, Pro-oxidant, Signaling pathways, coronary heart disease (CHD), lowdensity lipoprotein, anti-carcinogenic processes, anthocyanidins, quercetin, kaempferol, myricetin
Abstract: Evidence accumulates that a family of plant compounds, known as flavonoids, can prevent or slow down the progression of cardiovascular diseases, cancer, inflammatory and neurodegenerative diseases. Flavonoids are considered beneficial, this is often attributed to their powerful antioxidant properties. In this role, certain types of flavonoids are considered to be far more powerful than the two most common antioxidants, vitamin C and vitamin E, at preventing cellular damage brought on by free radicals. Interestingly, flavonoids exert those activities not only through direct radical scavenging, but also through regulating nitric oxide, and chelating metals. In addition, flavonoids are thought to facilitate/promote other important biological processes, resulting in modulation of enzymes, a decrease in leukocyte immobilization, inhibition of cell proliferation and angiogenesis, and effects on signaling pathways. The results of in vitro studies have demonstrated that the antioxidative property of flavonoids is unambiguous; however it is still not supported by strong consistent evidence in vivo. Therefore, the antioxidant theory as a mechanism of action of flavonoids is controversial. As a result, flavonoids are hypothesized to exert their activities partly through cell signaling pathways. This review intends to acquaint the reader with different pathways in which flavonoids function or might function. Furthermore, we will provide insight into the beneficial health effects of these substances.
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Cite this article as:
C.F. Bodewes Thomas, Luttikhold Joanna, F.M. van Stijn Mireille, Visser Marliek, van Norren Klaske, A.R. Vermeulen Mechteld and A.M. van Leeuwen Paul, Antioxidative Properties of Flavonoids, Current Organic Chemistry 2011; 15 (15) . https://dx.doi.org/10.2174/138527211796367282
DOI https://dx.doi.org/10.2174/138527211796367282 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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