Abstract
The cancer preventing effect of flavonoids is largely documented in literature. In addition to their nutritional value as cancer preventing agents, they have been studied as drug candidates in cancer treatment. Many mechanisms of action have been identified, including carcinogen inactivation, antiproliferation, cell cycle arrest, induction of apoptosis and differentiation, inhibition of angiogenesis, antioxidative activity and reversal of multidrug resistance. The diversity in the biological targets of flavonoids has led during the last twenty years to an extensive research toward medicinal chemistry of flavonoids with the aim to obtain anticancer drugs. Some anticancer agents derived from flavonoids are emerging as major anticancer drugs or chemosensitizers. This review will shed light on recent molecules obtained from efforts made on medicinal chemistry of flavonoids. A special focus will be made on flavonoid derivatives being studied in clinical trials.
Keywords: Anticancer potential, Clinical trials, Drug candidates, Flavonoids, Structural analog, radical-scavenging, ion-chelating abilities, reactive oxygen species (ROS), cytochrome P450, apoptosis, antiproliferation, angiogenic processes, structure-activity relationship (SAR), adenine moeity, isoflavones
Current Organic Chemistry
Title: Flavonoids as Anticancer Agents: Recent Progress and State of the Art?
Volume: 15 Issue: 15
Author(s): Estelle Genoux, Edwige Nicolle and Ahcene Boumendjel
Affiliation:
Keywords: Anticancer potential, Clinical trials, Drug candidates, Flavonoids, Structural analog, radical-scavenging, ion-chelating abilities, reactive oxygen species (ROS), cytochrome P450, apoptosis, antiproliferation, angiogenic processes, structure-activity relationship (SAR), adenine moeity, isoflavones
Abstract: The cancer preventing effect of flavonoids is largely documented in literature. In addition to their nutritional value as cancer preventing agents, they have been studied as drug candidates in cancer treatment. Many mechanisms of action have been identified, including carcinogen inactivation, antiproliferation, cell cycle arrest, induction of apoptosis and differentiation, inhibition of angiogenesis, antioxidative activity and reversal of multidrug resistance. The diversity in the biological targets of flavonoids has led during the last twenty years to an extensive research toward medicinal chemistry of flavonoids with the aim to obtain anticancer drugs. Some anticancer agents derived from flavonoids are emerging as major anticancer drugs or chemosensitizers. This review will shed light on recent molecules obtained from efforts made on medicinal chemistry of flavonoids. A special focus will be made on flavonoid derivatives being studied in clinical trials.
Export Options
About this article
Cite this article as:
Genoux Estelle, Nicolle Edwige and Boumendjel Ahcene, Flavonoids as Anticancer Agents: Recent Progress and State of the Art?, Current Organic Chemistry 2011; 15 (15) . https://dx.doi.org/10.2174/138527211796367363
DOI https://dx.doi.org/10.2174/138527211796367363 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Lipid Management for the Prevention of Cardiovascular Disease
Current Pharmaceutical Design β3-Adrenoceptor Control of Lower Genitourinary Tract Organs and Function in Male: An Overview
Current Drug Targets Strategies of overcoming the physiological barriers for tumor-targeted nano-sized drug delivery systems
Current Pharmaceutical Design Apoptosis Induction by Erucylphosphohomocholine via the 18 kDa Mitochondrial Translocator Protein: Implications for Cancer Treatment
Anti-Cancer Agents in Medicinal Chemistry Studies on Anticancer Activities of Lactoferrin and Lactoferricin
Current Protein & Peptide Science Computational Analysis of miRNA and their Gene Targets Significantly Involved in Colorectal Cancer Progression
MicroRNA Viral Vectors in Cancer Immunotherapy: Which Vector for Which Strategy?
Current Gene Therapy Systemic Treatment of Advanced Biliary Tract Carcinoma: Emerging Roles of Targeted Therapy and Molecular Profiling
Clinical Cancer Drugs Extra-Hepatic Isozymes from the CYP1 and CYP2 Families as Potential Chemotherapeutic Targets
Current Topics in Medicinal Chemistry Molecular Architecture of Tumor Suppressor p53
Current Topics in Medicinal Chemistry P-Glycoprotein Mediated Multidrug Resistance Reversal by Phytochemicals: A Review of SAR & Future Perspective for Drug Design
Current Topics in Medicinal Chemistry Pharmacological Inhibition of the Bcl-2 Family of Apoptosis Regulators as Cancer Therapy
Current Molecular Pharmacology Single-Photon Emission Computed Tomography Tracers for Predicting and Monitoring Cancer Therapy
Current Pharmaceutical Biotechnology Targeted Alpha Therapy with 227Th-trastuzumab of Intraperitoneal Ovarian Cancer in Nude Mice
Current Radiopharmaceuticals Molecular Targeted Agents Combined with Chemo-Radiation in the Treatment of Locally Advanced Cervix Cancer
Reviews on Recent Clinical Trials Potential Anti-cancer Drugs Commonly Used for Other Indications
Current Cancer Drug Targets Cyclin-Dependent Kinase 4/6 (Cdk4/6) Inhibitors: Perspectives in Cancer Therapy and Imaging
Mini-Reviews in Medicinal Chemistry Insight View on Possible Role of Fluoroquinolones in Cancer Therapy
Current Topics in Medicinal Chemistry Clinical, Prognostic and Therapeutic Significance of Heat Shock Proteins in Cancer
Current Drug Targets Porphyrins as Radiosensitizing Agents for Solid Neoplasms
Current Pharmaceutical Design