Abstract
Studies examining GABAB receptor agonists have reported effects on sleep including decreased sleep onset latency (SOL), increased sleep consolidation and increases in slow wave sleep (SWS). γ-hydroxybutyrate (GHB) is proposed to act as a GABAB receptor agonist; however, the mechanism of action of GHB is controversial. In addition, the GABAB receptor agonist, baclofen, has also been proposed to exert similar effects on sleep. The aim of this paper is to provide a review of the human clinical studies of sodium oxybate and baclofen regarding sleep and the treatment of sleep disorders including narcolepsy and insomnia, as well as other disorders involving disrupted sleep such as fibromyalgia.
Keywords: Sodium Oxybate, Gamma Hydroxybutyrate, GHB, Xyrem, Baclofen, GABA-B, Narcolepsy, Insomnia, fibromyalgia, hyperpolarization, -butyrolactone, succinic semialdehyde, schizophrenia, Polysomnograms, triazolam, episodic, cataplexy
Current Pharmaceutical Design
Title: A Review of Sodium Oxybate and Baclofen in the Treatment of Sleep Disorders
Volume: 17 Issue: 15
Author(s): Mark A. Brown and Christian Guilleminault
Affiliation:
Keywords: Sodium Oxybate, Gamma Hydroxybutyrate, GHB, Xyrem, Baclofen, GABA-B, Narcolepsy, Insomnia, fibromyalgia, hyperpolarization, -butyrolactone, succinic semialdehyde, schizophrenia, Polysomnograms, triazolam, episodic, cataplexy
Abstract: Studies examining GABAB receptor agonists have reported effects on sleep including decreased sleep onset latency (SOL), increased sleep consolidation and increases in slow wave sleep (SWS). γ-hydroxybutyrate (GHB) is proposed to act as a GABAB receptor agonist; however, the mechanism of action of GHB is controversial. In addition, the GABAB receptor agonist, baclofen, has also been proposed to exert similar effects on sleep. The aim of this paper is to provide a review of the human clinical studies of sodium oxybate and baclofen regarding sleep and the treatment of sleep disorders including narcolepsy and insomnia, as well as other disorders involving disrupted sleep such as fibromyalgia.
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Cite this article as:
A. Brown Mark and Guilleminault Christian, A Review of Sodium Oxybate and Baclofen in the Treatment of Sleep Disorders, Current Pharmaceutical Design 2011; 17 (15) . https://dx.doi.org/10.2174/138161211796197098
DOI https://dx.doi.org/10.2174/138161211796197098 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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