Abstract
After the discovery and characterization of the H3R and H4R receptors, they have become widely anticipated as potential therapeutic agents in the treatment of sleep disorders. In preliminary studies, histamine H3 receptor (H3R) antagonists and inverse agonists have demonstrated promise in the treatment of sleep disorders associated with excessive daytime sleepiness. This review article summarizes the current research in this area and characteristics of H3R and H3R antagonists and inverse agonists in development.
Keywords: Histamine, H3 receptor, H3R antagonists, histamine H3 receptor H3R inverse agonists, narcolepsy treatment, excessive daytime sleepiness, antihistamine, sleepiness, narcolepsy, metabotropic, tuberomammillary, diurnal, orexin, preoptic, accumbens, globus pallidus, substantia nigra, presynaptically, norepinephrine, thioperamide
Current Pharmaceutical Design
Title: Histamine H3 Receptor (H3R) Antagonists and Inverse Agonists in the Treatment of Sleep Disorders
Volume: 17 Issue: 15
Author(s): Meredith Broderick and Tony Masri
Affiliation:
Keywords: Histamine, H3 receptor, H3R antagonists, histamine H3 receptor H3R inverse agonists, narcolepsy treatment, excessive daytime sleepiness, antihistamine, sleepiness, narcolepsy, metabotropic, tuberomammillary, diurnal, orexin, preoptic, accumbens, globus pallidus, substantia nigra, presynaptically, norepinephrine, thioperamide
Abstract: After the discovery and characterization of the H3R and H4R receptors, they have become widely anticipated as potential therapeutic agents in the treatment of sleep disorders. In preliminary studies, histamine H3 receptor (H3R) antagonists and inverse agonists have demonstrated promise in the treatment of sleep disorders associated with excessive daytime sleepiness. This review article summarizes the current research in this area and characteristics of H3R and H3R antagonists and inverse agonists in development.
Export Options
About this article
Cite this article as:
Broderick Meredith and Masri Tony, Histamine H3 Receptor (H3R) Antagonists and Inverse Agonists in the Treatment of Sleep Disorders, Current Pharmaceutical Design 2011; 17 (15) . https://dx.doi.org/10.2174/138161211796197133
DOI https://dx.doi.org/10.2174/138161211796197133 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
"Tuberculosis Prevention, Diagnosis and Drug Discovery"
The Nobel Prize-winning discoveries of Mycobacterium tuberculosis and streptomycin have enabled an appropriate diagnosis and an effective treatment of tuberculosis (TB). Since then, many newer diagnosis methods and drugs have been saving millions of lives. Despite advances in the past, TB is still a leading cause of infectious disease mortality ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Emerging and re-emerging diseases
Faced with a possible endemic situation of COVID-19, the world has experienced two important phenomena, the emergence of new infectious diseases and/or the resurgence of previously eradicated infectious diseases. Furthermore, the geographic distribution of such diseases has also undergone changes. This context, in turn, may have a strong relationship with ...read more
Melanoma and Non-Melanoma Skin Cancer Treatment: Standard of Care and Recent Advances
In this thematic issue, we aim to provide a standard of care of the diagnosis and treatment of melanoma and non-melanoma skin cancer. The editor will invite authors from different countries who will write review articles of melanoma and non-melanoma skin cancers. The Diagnosis, Staging, Surgical Treatment, Non-Surgical Treatment all ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
5-HT1 Receptors
Current Drug Targets - CNS & Neurological Disorders Benefits of Resistance Training in Older Adults
Current Aging Science RNA Splicing Manipulation: Strategies to Modify Gene Expression for a Variety of Therapeutic Outcomes
Current Gene Therapy Current and Future Therapeutic Strategies for Parkinsons Disease
Current Pharmaceutical Design Subtype Classification by Polymerase and Gag Genes of HIV-1 Iranian Sequences Registered in the NCBI GenBank
Current Proteomics Mechanisms of Neurovascular Dysfunction in Acute Ischemic Brain
Current Medicinal Chemistry Amyloidogenesis of Natively Unfolded Proteins
Current Alzheimer Research Conditional Tat Protein Brain Expression in the GT-tg Bigenic Mouse Induces Cerebral Fractional Anisotropy Abnormalities
Current HIV Research Inflammatory Cardiovascular Risk Markers in Obstructive Sleep Apnoea Syndrome
Cardiovascular & Hematological Agents in Medicinal Chemistry Delirium in Older Patients – A Review
Current Psychiatry Reviews Patent Selections
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Automatic Detection of Cognitive Impairments through Acoustic Analysis of Speech
Current Alzheimer Research Editorial [Hot Topic New Clinical Indications of Antipsychotic Medications Guest Editors: Filippo Bogetto and Silvio Bellino]
Current Psychopharmacology Effect of Antipsychotic Drugs on Cerebrovascular Morbidity and Mortality: A Systematic Review
Current Drug Therapy Dance for People with Alzheimer’s Disease: A Systematic Review
Current Alzheimer Research DNA Secondary Structure at Chromosomal Fragile Sites in Human Disease
Current Genomics Exosomes and Exosomal microRNAs in Age-associated Stroke
Current Vascular Pharmacology Vitamin-mediated immune regulation in the development of inflammatory diseases
Endocrine, Metabolic & Immune Disorders - Drug Targets Prospective Function of Different Antioxidant Containing Natural Products in the Treatment of Neurodegenerative Diseases
CNS & Neurological Disorders - Drug Targets Bipolar Spectrum Disorder: Origins and State of the Art
Current Psychiatry Reviews