Abstract
Several mechanisms function in the endocytic regulation of the Wnt/β-catenin signaling pathway to promote or interrupt the progression of critical cellular processes during embryonic development or disease progression. Endocytosis was initially associated with the formation of a morphogen gradient of Wnt/β-catenin signaling, but current studies have documented its role in defining signal intensity and propagation. Although the exact parameters that define and dictate the internalization of Wnt receptors and co-receptors via clathrin- or caveolae-mediated endocytosis remain unclear, new studies indicate that the trafficking of the signaling pool of the dual-function protein β-catenin from sites of cell-cell contacts serve as a mechanism to finely tune the outcome of the Wnt/β-catenin signaling. This review discusses the endocytic regulation of Wnt/ β-catenin signaling that occurs at the cell surface as well as within the cell.
Keywords: Endocytosis, Wnt, β-catenin, LRP6, cell adhesion, cell signaling, GTPases, transcription factor, endocytic portal, trafficking
Current Drug Targets
Title: Endocytic Trafficking and Wnt/β-Catenin Signaling
Volume: 12 Issue: 8
Author(s): Oscar Pellon-Cardenas, Jill Schweitzer and Crislyn D'Souza-Schorey
Affiliation:
Keywords: Endocytosis, Wnt, β-catenin, LRP6, cell adhesion, cell signaling, GTPases, transcription factor, endocytic portal, trafficking
Abstract: Several mechanisms function in the endocytic regulation of the Wnt/β-catenin signaling pathway to promote or interrupt the progression of critical cellular processes during embryonic development or disease progression. Endocytosis was initially associated with the formation of a morphogen gradient of Wnt/β-catenin signaling, but current studies have documented its role in defining signal intensity and propagation. Although the exact parameters that define and dictate the internalization of Wnt receptors and co-receptors via clathrin- or caveolae-mediated endocytosis remain unclear, new studies indicate that the trafficking of the signaling pool of the dual-function protein β-catenin from sites of cell-cell contacts serve as a mechanism to finely tune the outcome of the Wnt/β-catenin signaling. This review discusses the endocytic regulation of Wnt/ β-catenin signaling that occurs at the cell surface as well as within the cell.
Export Options
About this article
Cite this article as:
Pellon-Cardenas Oscar, Schweitzer Jill and D'Souza-Schorey Crislyn, Endocytic Trafficking and Wnt/β-Catenin Signaling, Current Drug Targets 2011; 12 (8) . https://dx.doi.org/10.2174/138945011795906552
DOI https://dx.doi.org/10.2174/138945011795906552 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
Call for Papers in Thematic Issues
New drug therapy for eye diseases
Eyesight is one of the most critical senses, accounting for over 80% of our perceptions. Our quality of life might be significantly affected by eye disease, including glaucoma, diabetic retinopathy, dry eye, etc. Although the development of microinvasive ocular surgery reduces surgical complications and improves overall outcomes, medication therapy is ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Telocytes as a Source of Progenitor Cells in Regeneration and Repair Through Granulation Tissue
Current Stem Cell Research & Therapy Probiotics and Different Efficacy, How it can be Managed?
Current Drug Therapy Cucurbitacins and the Immune System: Update in Research on Anti- inflammatory, Antioxidant, and Immunomodulatory Mechanisms
Current Medicinal Chemistry Investigation of Novel Chemical Inhibitors of Human Lysosomal Acid Lipase: Virtual Screening and Molecular Docking Studies
Combinatorial Chemistry & High Throughput Screening Rotundic Acid Regulates the Effects of Let-7f-5p on Caco2 Cell Proliferation
Anti-Cancer Agents in Medicinal Chemistry Emerging Vascular Risk Factors in Women: Any Differences from Men?
Current Medicinal Chemistry pH-Dependent Behavior of Novel Gellan Beads Loaded with Naproxen
Current Drug Delivery Identification of Apoptotic Drugs: Multiparametric Evaluation in Cultured Hepatocytes
Current Medicinal Chemistry Adrenergic and V1-ergic Agonists/Antagonists Affecting Recovery from Brain Trauma in the Lund Project Act on Astrocytes
Current Signal Transduction Therapy Chitosan: A Propitious Biopolymer for Drug Delivery
Current Drug Delivery Monitoring of Treatment-Induced Apoptosis in Oncology with PET and SPECT
Current Pharmaceutical Design Natural Products as Promising Drug Candidates for the Treatment of Alzheimer’s Disease: Molecular Mechanism Aspect
Current Neuropharmacology NK-1 Receptor Antagonists: A New Paradigm in Pharmacological Therapy
Current Medicinal Chemistry Mechanisms Involved in Apoptosis Events Contributing to Sepsis-Induced Myocardial Dysfunction
Current Drug Therapy Adjudin - A Male Contraceptive with Other Biological Activities
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Probing Multidrug Resistance P-glycoprotein Transporter Activity with SPECT Radiopharmaceuticals
Current Topics in Medicinal Chemistry Interrelationships of Circulating Tumor Cells with Metastasis and Thrombosis: Role of MicroRNAs
Current Pharmaceutical Design Semaphorins and their Receptors in Stem and Cancer Cells
Current Medicinal Chemistry Fucose Specific Lectins in Cancer Research and Diagnosis
Drug Design Reviews - Online (Discontinued) Modulation of Cell Death in Age-Related Diseases
Current Pharmaceutical Design