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Current Organic Chemistry

Editor-in-Chief

ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Aromatic Oligoamide Foldamers: A Paradigm for Structure – Property Relationship

Author(s): Quan Gan, Ying Wang and Hua Jiang

Volume 15, Issue 9, 2011

Page: [1293 - 1301] Pages: 9

DOI: 10.2174/138527211795378227

Price: $65

Abstract

Aromatic oligoamide foldamers whose helical structures were stabilized by intramolecular hydrogen bindings between consecutive units not only can mimic the secondary or tertiary structures of its natural counterparts but also provide alternative approaches to study the properties of biopolymers in artificial systems. Aromatic oligoamide foldamers are sequence-specific oligomers as demonstrated in peptides and DNA, while variation of orientation and size of aromatic monomers and lengths of oligomers can generate many foldamers with desirable structures and in turn lead to different properties. In this article, we illustrate the structure-property relationships of aromatic oligoamide foldamers reported by us and collaborators.

Keywords: Aromatic oligoamides, foldamers, hydrogen bonds, helices, helical capsules, self-assembly, helical structures, double helices, biological activities, selfassembly, Homodouble helices, Heterodouble helices, NMR spectroscopy, DMSO, NOESY, H DOSY, F NMR


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