Pulmonary Drug Delivery System: A Novel Approach for Drug Delivery

Anupama      Singh; Rishabha      Malviya; Pramod      K. Sharma

Abstract

In present study authors review all aspects of pulmonary drug delivery system; including need of drug delivery, different approaches for drug delivery and recent advancement in pulmonary drug delivery system. Review deals with drug targeting to pulmonary region for the treatment of various diseases such as chronic obstructive pulmonary disease, lung cancer, cystic fibrosis, tuberculosis, asthma, etc. All these disorders are difficult to be effectively cured through conventional modes of dosage system rather novel delivery systems have been developed which proved to be more site specific and less toxic. Apart from various formulations, different delivery devices such as metered dose inhalers (MDI), dry powder inhalers (DPI), nebulizers, aerosolizers, etc. have also improved drug targeting efficacy and reduced dose size in a more efficient manner. This review contains mainly the tabulated description of different categories of drugs and devices recently available in the market which makes it easily accessible for the researchers. Proteins, other biologicals and different marketed products are also successfully available to be delivered through pulmonary route for the better patient management. It can be concluded from whole study that different pulmonary delivery system possesses certain specificity for dosage formulations and serves as an important tool to deliver drugs to the target site.

Keywords: Pulmonary drug delivery, targeted drug delivery, delivery devices, protein and peptide delivery, Micronization, Spray freeze drying, Supercritical Fluid Crystallization, Nanoparticles, Insulin, Nanosuspensions