Abstract
Since storage of excess fat in peripheral tissues is a contributing factor leading to obesity and type II diabetes, many investigators are studying the key lipid metabolizing enzymes found in adipose tissue as drug targets to reduce excess fat. The availability of cultured cell lines and primary stem cells, preadipocyetes, and adipocytes has facilitated therapeutic approaches aimed at targeting fat storage. This includes developing inhibitors for enzymes regulating lipogenesis in these cells, such as acetyl-CoA carboxylase, fatty acid synthase, diacylgycerol acyl transferase, and stearoyl CoA desaturase. High level expression of each protein is often used to confirm stem cells have undergone adipogenesis. Inhibition of these enzymes often leads to reduced fat cell fat differentiation and lipid synthesis and may also contribute to increased fat oxidation and energy expenditure. This article reviews developments in pharmaceutical research on these enzymes, with particular emphasis on the role of the enzymes in adipose tissue metabolism.
Keywords: Acetyl-CoA carboxylase, adipogenesis, adipocytes, diabetes, fatty acid synthase, diacylgycerol acyl transferase, obesity, stearoyl CoA desaturase
Current Pharmaceutical Design
Title: Lipogenic Enzymes as Therapeutic Targets for Obesity and Diabetes
Volume: 17 Issue: 4
Author(s): James M. Lenhard
Affiliation:
Keywords: Acetyl-CoA carboxylase, adipogenesis, adipocytes, diabetes, fatty acid synthase, diacylgycerol acyl transferase, obesity, stearoyl CoA desaturase
Abstract: Since storage of excess fat in peripheral tissues is a contributing factor leading to obesity and type II diabetes, many investigators are studying the key lipid metabolizing enzymes found in adipose tissue as drug targets to reduce excess fat. The availability of cultured cell lines and primary stem cells, preadipocyetes, and adipocytes has facilitated therapeutic approaches aimed at targeting fat storage. This includes developing inhibitors for enzymes regulating lipogenesis in these cells, such as acetyl-CoA carboxylase, fatty acid synthase, diacylgycerol acyl transferase, and stearoyl CoA desaturase. High level expression of each protein is often used to confirm stem cells have undergone adipogenesis. Inhibition of these enzymes often leads to reduced fat cell fat differentiation and lipid synthesis and may also contribute to increased fat oxidation and energy expenditure. This article reviews developments in pharmaceutical research on these enzymes, with particular emphasis on the role of the enzymes in adipose tissue metabolism.
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Cite this article as:
M. Lenhard James, Lipogenic Enzymes as Therapeutic Targets for Obesity and Diabetes, Current Pharmaceutical Design 2011; 17 (4) . https://dx.doi.org/10.2174/138161211795164185
DOI https://dx.doi.org/10.2174/138161211795164185 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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