Abstract
Lactoferrin, a member of the “Siderophilin” family, is an iron binding glycoprotein. Lactoferrin is produced by various exocrine glands in our body and is abundantly present in milk and colostrums. The uniqueness of lactoferrin as a skeletal regenerative molecule lies in its ability to favorably modulate the responses of the various cell types involved in musculoskeletal regeneration. Lactoferrin exhibits pleiotropic functions and recent studies indicate that lactoferrin promotes the proliferation and differentiation of osteoblast cells and inhibits osteoclast-mediated bone resorption. Human lactoferrin is also known to promote neovascularization. This review aims to summarize the most recent studies on lactoferrin focusing on its anabolic effect to bone tissue and the ability to modulate immune responses with specific focus on osteoimmunology.
Keywords: lactoferrin, bone regeneration, immunoregulation, angiogenesis, Siderophilin, glycoprotein, skeletal tissue, glycosylation, osteoclastogenesis, immuno-expression
Current Medicinal Chemistry
Title: Lactoferrin: A Biologically Active Molecule for Bone Regeneration
Volume: 18 Issue: 8
Author(s): A. A. Amini and L. S. Nair
Affiliation:
Keywords: lactoferrin, bone regeneration, immunoregulation, angiogenesis, Siderophilin, glycoprotein, skeletal tissue, glycosylation, osteoclastogenesis, immuno-expression
Abstract: Lactoferrin, a member of the “Siderophilin” family, is an iron binding glycoprotein. Lactoferrin is produced by various exocrine glands in our body and is abundantly present in milk and colostrums. The uniqueness of lactoferrin as a skeletal regenerative molecule lies in its ability to favorably modulate the responses of the various cell types involved in musculoskeletal regeneration. Lactoferrin exhibits pleiotropic functions and recent studies indicate that lactoferrin promotes the proliferation and differentiation of osteoblast cells and inhibits osteoclast-mediated bone resorption. Human lactoferrin is also known to promote neovascularization. This review aims to summarize the most recent studies on lactoferrin focusing on its anabolic effect to bone tissue and the ability to modulate immune responses with specific focus on osteoimmunology.
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Cite this article as:
A. Amini A. and S. Nair L., Lactoferrin: A Biologically Active Molecule for Bone Regeneration, Current Medicinal Chemistry 2011; 18 (8) . https://dx.doi.org/10.2174/092986711795029744
DOI https://dx.doi.org/10.2174/092986711795029744 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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