Abstract
Non-alcoholic fatty liver disease is regarded as the hepatic manifestation of metabolic syndrome and is an important and common cause of chronic liver disease with a potential to develop end-stage liver disease. While important advances in the pathophysiology have been achieved using genetically modified and diet-induced animal models, in-vitro models have been only recently proposed. These models include primary culture and immortalized cell lines. Here we critically review the characteristics of the in vitro models described, the advantages and limitations of the in vitro approach, and the results derived.
Keywords: Fatty acids, fatty liver, biomedical research, biological models, Non-alcoholic, hepatic manifestation, metabolic syndrome, end-stage liver disease, diet-induced animal models
Current Medicinal Chemistry
Title: In Vitro Models for the Study of Non-Alcoholic Fatty Liver Disease
Volume: 18 Issue: 7
Author(s): N. C. Chavez-Tapia, N. Rosso and C. Tiribelli
Affiliation:
Keywords: Fatty acids, fatty liver, biomedical research, biological models, Non-alcoholic, hepatic manifestation, metabolic syndrome, end-stage liver disease, diet-induced animal models
Abstract: Non-alcoholic fatty liver disease is regarded as the hepatic manifestation of metabolic syndrome and is an important and common cause of chronic liver disease with a potential to develop end-stage liver disease. While important advances in the pathophysiology have been achieved using genetically modified and diet-induced animal models, in-vitro models have been only recently proposed. These models include primary culture and immortalized cell lines. Here we critically review the characteristics of the in vitro models described, the advantages and limitations of the in vitro approach, and the results derived.
Export Options
About this article
Cite this article as:
C. Chavez-Tapia N., Rosso N. and Tiribelli C., In Vitro Models for the Study of Non-Alcoholic Fatty Liver Disease, Current Medicinal Chemistry 2011; 18 (7) . https://dx.doi.org/10.2174/092986711794940842
DOI https://dx.doi.org/10.2174/092986711794940842 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Surgical Complications of Hyperglycaemia
Current Diabetes Reviews Vascular Risk Factors and Lesions of Vascular Nature in Magnetic Resonance as Predictors of Progression to Dementia in Patients with Mild Cognitive Impairment
Current Alzheimer Research Role of Immune Cells in Diabetic Kidney Disease
Current Gene Therapy Biological and Pharmacological Effects of Gamma-oryzanol: An Updated Review of the Molecular Mechanisms
Current Pharmaceutical Design C-Reactive Protein: Interaction with the Vascular Endothelium and Possible Role in Human Atherosclerosis
Current Pharmaceutical Design Adiposity and the Gut - The Role of Gut Hormones
Current Nutrition & Food Science Prediction of Disease-Related Genes Based on Hybrid Features
Current Proteomics Treatments for Obesity-Related Hypertension
Current Hypertension Reviews The Biology of the Peroxisome Proliferator-activated Receptor System in the Female Reproductive Tract
Current Pharmaceutical Design Hitting the Jackpot Twice: Identifying and Patenting Gene Tests Related to Muscle Lipid Accumulation for Meat Quality in Animals and Type 2 Diabetes/Obesity in Humans
Recent Patents on DNA & Gene Sequences Association between HbA1C (Glycated Hemoglobin) and Clinical Outcomes in Patients with Subarachnoid Hemorrhage After Neuro-intervention
Current Neurovascular Research Uteroplacental Circulation and Fetal Vascular Function and Development
Current Vascular Pharmacology Dietary Additive Probiotics Modulation of the Intestinal Microbiota
Protein & Peptide Letters Polyphenols in Disease: from Diet to Supplements
Current Pharmaceutical Biotechnology Do Adenosine Receptors Offer New Therapeutic Options for Diabetic Nephropathy?
Current Vascular Pharmacology Rhodanine as a Privileged Scaffold in Drug Discovery
Current Medicinal Chemistry Establishing Maternal Tolerance: The Role of Regulatory T Cells (Tregs) in Pregnancy and Pathophysiology of Preeclampsia
Current Women`s Health Reviews Cardiovascular Disease Risk of Type 2 Diabetes Mellitus and Metabolic Syndrome: Focus on Aggressive Management of Dyslipidemia
Current Diabetes Reviews Platelet Function Testing in Atherothrombotic Disease
Current Pharmaceutical Design Combination of SGLT-2 Inhibitors and GLP-1 Receptor Agonists: Potential Benefits in Surrogate and Hard Endpoints
Current Pharmaceutical Design