Abstract
Non-alcoholic fatty liver disease is regarded as the hepatic manifestation of metabolic syndrome and is an important and common cause of chronic liver disease with a potential to develop end-stage liver disease. While important advances in the pathophysiology have been achieved using genetically modified and diet-induced animal models, in-vitro models have been only recently proposed. These models include primary culture and immortalized cell lines. Here we critically review the characteristics of the in vitro models described, the advantages and limitations of the in vitro approach, and the results derived.
Keywords: Fatty acids, fatty liver, biomedical research, biological models, Non-alcoholic, hepatic manifestation, metabolic syndrome, end-stage liver disease, diet-induced animal models
Current Medicinal Chemistry
Title: In Vitro Models for the Study of Non-Alcoholic Fatty Liver Disease
Volume: 18 Issue: 7
Author(s): N. C. Chavez-Tapia, N. Rosso and C. Tiribelli
Affiliation:
Keywords: Fatty acids, fatty liver, biomedical research, biological models, Non-alcoholic, hepatic manifestation, metabolic syndrome, end-stage liver disease, diet-induced animal models
Abstract: Non-alcoholic fatty liver disease is regarded as the hepatic manifestation of metabolic syndrome and is an important and common cause of chronic liver disease with a potential to develop end-stage liver disease. While important advances in the pathophysiology have been achieved using genetically modified and diet-induced animal models, in-vitro models have been only recently proposed. These models include primary culture and immortalized cell lines. Here we critically review the characteristics of the in vitro models described, the advantages and limitations of the in vitro approach, and the results derived.
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Cite this article as:
C. Chavez-Tapia N., Rosso N. and Tiribelli C., In Vitro Models for the Study of Non-Alcoholic Fatty Liver Disease, Current Medicinal Chemistry 2011; 18 (7) . https://dx.doi.org/10.2174/092986711794940842
DOI https://dx.doi.org/10.2174/092986711794940842 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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