Abstract
An overview of anticancer active spirocyclopropanes of the illudin class is provided. After a short introduction on the history and general chemistry of illudins M and S, new discoveries concerning their mode of action and metabolism are reported as well as new synthetic endeavors towards derivatives with improved selectivity for and efficacy against cancer cells. In addition, common and recently tapped biological sources and isolation procedures for known and new illudins are discussed. Pertinent literature is covered up to 2010.
Keywords: Alkylating agents, illudins, irofulven, anticancer drugs, fungal agents, spirocyclopropanes, metabolism, bionucleophiles, cyclophosphamide, basidiomycetes, lantern mushroom, mitomycins
Current Medicinal Chemistry
Title: Anticancer Active Illudins: Recent Developments of a Potent Alkylating Compound Class
Volume: 18 Issue: 6
Author(s): R. Schobert, S. Knauer, S. Seibt and B. Biersack
Affiliation:
Keywords: Alkylating agents, illudins, irofulven, anticancer drugs, fungal agents, spirocyclopropanes, metabolism, bionucleophiles, cyclophosphamide, basidiomycetes, lantern mushroom, mitomycins
Abstract: An overview of anticancer active spirocyclopropanes of the illudin class is provided. After a short introduction on the history and general chemistry of illudins M and S, new discoveries concerning their mode of action and metabolism are reported as well as new synthetic endeavors towards derivatives with improved selectivity for and efficacy against cancer cells. In addition, common and recently tapped biological sources and isolation procedures for known and new illudins are discussed. Pertinent literature is covered up to 2010.
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Cite this article as:
Schobert R., Knauer S., Seibt S. and Biersack B., Anticancer Active Illudins: Recent Developments of a Potent Alkylating Compound Class, Current Medicinal Chemistry 2011; 18 (6) . https://dx.doi.org/10.2174/092986711794927766
DOI https://dx.doi.org/10.2174/092986711794927766 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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