Abstract
Apoptosis of bronchial epithelial cells and the phagocytic clearance of these cells by alveolar macrophages (a process termed efferocytosis) are integral processes leading to repair of airway epithelial injury. Efferocytosis allows for the removal of apoptotic material with minimal inflammation and prevents the development of secondary necrosis and ongoing inflammation. Defective efferocytosis and the increased presence of apoptotic cells have been identified in the airways of subjects with chronic obstructive pulmonary disease (COPD). There are three major potential causes for this accumulation of apoptotic cells: (i) increased apoptosis per se as a result of an increase in apoptotic mediators, (ii) defects in the recognition of apoptotic cells by AM and (iii) failure to clear the unwanted cells by the process of efferocytosis. The implications of these processes in COPD and novel treatment strategies aimed at improving clearance of apoptotic cells form the focus of the present review.
Keywords: Alveolar macrophage, apoptosis, collectin, COPD, efferocytosis, phagocytosis, tobacco smoke, protease, granzyme, perforin, oxidative stress, Mannose receptor
Current Drug Targets
Title: Airway Clearance of Apoptotic Cells in COPD
Volume: 12 Issue: 4
Author(s): Violet R.S. Mukaro and Sandra Hodge
Affiliation:
Keywords: Alveolar macrophage, apoptosis, collectin, COPD, efferocytosis, phagocytosis, tobacco smoke, protease, granzyme, perforin, oxidative stress, Mannose receptor
Abstract: Apoptosis of bronchial epithelial cells and the phagocytic clearance of these cells by alveolar macrophages (a process termed efferocytosis) are integral processes leading to repair of airway epithelial injury. Efferocytosis allows for the removal of apoptotic material with minimal inflammation and prevents the development of secondary necrosis and ongoing inflammation. Defective efferocytosis and the increased presence of apoptotic cells have been identified in the airways of subjects with chronic obstructive pulmonary disease (COPD). There are three major potential causes for this accumulation of apoptotic cells: (i) increased apoptosis per se as a result of an increase in apoptotic mediators, (ii) defects in the recognition of apoptotic cells by AM and (iii) failure to clear the unwanted cells by the process of efferocytosis. The implications of these processes in COPD and novel treatment strategies aimed at improving clearance of apoptotic cells form the focus of the present review.
Export Options
About this article
Cite this article as:
R.S. Mukaro Violet and Hodge Sandra, Airway Clearance of Apoptotic Cells in COPD, Current Drug Targets 2011; 12 (4) . https://dx.doi.org/10.2174/138945011794751609
DOI https://dx.doi.org/10.2174/138945011794751609 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
Call for Papers in Thematic Issues
New drug therapy for eye diseases
Eyesight is one of the most critical senses, accounting for over 80% of our perceptions. Our quality of life might be significantly affected by eye disease, including glaucoma, diabetic retinopathy, dry eye, etc. Although the development of microinvasive ocular surgery reduces surgical complications and improves overall outcomes, medication therapy is ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
N6-methyladenine RNA Modification (m<sup>6</sup>A): An Emerging Regulator of Metabolic Diseases
Current Drug Targets The Blood-Brain Barrier as a Cause of Obesity
Current Pharmaceutical Design Vildagliptin Restores Renal Myogenic Function and Attenuates Renal Sclerosis Independently of Effects on Blood Glucose or Proteinuria in Zucker Diabetic Fatty Rat
Current Vascular Pharmacology Carbon Monoxide: Medicinal Chemistry and Biological Effects
Current Medicinal Chemistry Adrenomedullin in Vascular Endothelial Injury and Combination Therapy: Time for a New Paradigm
Current Vascular Pharmacology Schizophrenia: A Systematic Review of the Disease State, Current Therapeutics and their Molecular Mechanisms of Action
Current Medicinal Chemistry Importance of Oral Health in Pregnancy: A Mini-symposium
Current Women`s Health Reviews Patent Selections:
Recent Patents on Cardiovascular Drug Discovery Synthesis, Antioxidant and Anti-inflammatory Properties of an Apocynin- Derived Dihydrocoumarin
Medicinal Chemistry Patent Selections
Recent Patents on CNS Drug Discovery (Discontinued) Renovascular Hypertension: Novel Insights
Current Hypertension Reviews Engineered Probiotic and Prebiotic Nutraceutical Supplementations in Combating Non-communicable Disorders: A Review
Current Pharmaceutical Biotechnology Molecular Mechanisms of Restenosis After Percutaneous Peripheral Angioplasty and Approach to Endovascular Therapy
Current Drug Targets - Cardiovascular & Hematological Disorders (Section A: Molecular, Structural, and Cellular Biology of Drug Transporters) Mammalian Nucleoside Transporters
Current Drug Metabolism Teratological Consequences of Nitric Oxide Synthesis Inhibition
Current Pharmaceutical Design Aging in the Perspective of Integrative Medicine, Psychoneuroendocrineimmunology and Hormesis
Current Aging Science Transforming Growth Factor β Signaling Perturbation in the Loeys-Dietz Syndrome
Current Medicinal Chemistry Simvastatin: Review of Updates on Recent Trends in Pharmacokinetics, Pharmacodynamics, Drug–drug Interaction, Impurities and Analytical Methods
Current Pharmaceutical Analysis Current Advances and Future Challenges in Adenoviral Vector Biology and Targeting
Current Gene Therapy microRNA as Biomarkers and Regulator of Cardiovascular Development and Disease
Current Pharmaceutical Design